| Tag | Content |
|---|
| CPLM ID | CPLM-024207 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 60 kDa lysophospholipase |
Protein Synonyms/Alias | L-asparaginase; L-asparagine amidohydrolase; Platelet-activating factor acetylhydrolase; PAF acetylhydrolase |
Gene Name | Aspg |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 225 | LVRKACGKSHLVVHS | ubiquitination | [1] | | 261 | TFLQPPLKGVVMETF | ubiquitination | [1] | | 276 | GSGNGPTKPDLLQEL | ubiquitination | [1] | | 354 | DRKKLLAKDLRGEMT | ubiquitination | [1] | | 427 | LDRDLNLKDYSGQTP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities. |
Sequence Annotation | REPEAT 141 170 ANK 1.
REPEAT 396 426 ANK 2.
REPEAT 430 459 ANK 3.
REPEAT 463 492 ANK 4.
REPEAT 530 559 ANK 5.
REGION 41 350 Asparaginase.
REGION 84 86 Substrate binding (By similarity).
REGION 116 117 Substrate binding (By similarity).
ACT_SITE 19 19 Acyl-ester intermediate (By similarity).
MOD_RES 387 387 Phosphoserine. |
Keyword | ANK repeat; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 564 AA |
Protein Sequence | MARAMGPERR LLAIYTGGTI GMRSEGGVLV PGRGLAAVLK TLHMFHDEEY AQAHSLPEDT 60
LVLPPASPDQ RIIYTVLECQ PLFDSSDMTI TEWVQIAQTI ERHYAQYQGF VVIHGTDTMA 120
FAASVLSFML ENLQKPVVLT GAQVPIHALW SDGRENLLGA LLMAGQYVIP EVCLFFQNQL 180
FRGNRTTKVD ARRFAAFCSP NLPPLATVGA DVTINRELVR KACGKSHLVV HSSMEPDVGL 240
LRLYPGIPAS LVRTFLQPPL KGVVMETFGS GNGPTKPDLL QELRVAAEQG LIIVNCTHCL 300
QGAVTSDYAS GMAMAGAGIV SGFDMTSEAA LAKLSYVLGQ PGLSLNDRKK LLAKDLRGEM 360
TLPATDVLLQ DGMLGCRVAW LLSMNGSQEA DTMKDVLLPG LALAAAHAGD LDTLQAFVEL 420
DRDLNLKDYS GQTPLHVAAR RGHAAVVTML LQRGADVDAR NEDGQSPLLL AVRGRHQSVI 480
GLLRAAGARL SPQELEDVGT ELCRLASRGD SEGLRAWWQA GADLGQPDYD GHCALQVAEA 540
AGNADVVALL QSFKDSVCAQ PQPH 564 |
Gene Ontology | GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:EC. GO:0004067; F:asparaginase activity; IEA:EC. GO:0004622; F:lysophospholipase activity; IEA:EC. GO:0006528; P:asparagine metabolic process; IEA:Compara. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0006644; P:phospholipid metabolic process; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |