CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Non-histone chromosomal protein HMG-14 
Protein Synonyms/Alias
  
Gene Name
 HMGN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
30SSAEGAAKEEPKRRSacetylation[1, 2, 3]
30SSAEGAAKEEPKRRSubiquitination[3, 4]
43RSARLSAKPPAKVEAacetylation[3]
47LSAKPPAKVEAKPKKacetylation[5]
77GKRGAKGKQAEVANQubiquitination[6]
87EVANQETKEDLPAENubiquitination[6, 7]
98PAENGETKTEESPASubiquitination[6, 7]
111ASDEAGEKEAKSD**ubiquitination[6]
114EAGEKEAKSD*****ubiquitination[3]
Reference
 [1] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 116 AA 
Protein Sequence
MFEPNSPRRG GARYQWPEGA QVSSAEGAAK EEPKRRSARL SAKPPAKVEA KPKKAAAKDK 60
SSDKKVQTKG KRGAKGKQAE VANQETKEDL PAENGETKTE ESPASDEAGE KEAKSD 116 
Gene Ontology
 GO:0000785; C:chromatin; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0031492; F:nucleosomal DNA binding; IEA:InterPro. 
Interpro
 IPR000079; HMGN_fam. 
Pfam
 PF01101; HMG14_17 
SMART
 SM00527; HMG17 
PROSITE
 PS00355; HMG14_17 
PRINTS
 PR00925; NONHISHMG17.