UniProt Accession

 IDI1_RAT; O35760; Q5FVT3 

Genbank Protein ID

 AF003835; BC089786 

Genbank Nucleotide ID

 AAC53282.1; AAH89786.2 

Protein Name

 Isopentenyl-diphosphate Delta-isomerase 1 

Protein Synonyms/Alias

 Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1 

Gene Name

 Idi1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
113	RAAQRRLKAELGIPL	acetylation	[1]
180	YVSKEELKEILKKEA	acetylation	[1]
192	KEARGEIKLTPWFKI	acetylation	[1]
223	SPFVDHEKIHRM***	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). 

Sequence Annotation

 DOMAIN 49 199 Nudix hydrolase.
 MOTIF 225 227 Microbody targeting signal.
 ACT_SITE 86 86 By similarity.
 ACT_SITE 148 148 By similarity.
 METAL 40 40 Magnesium (By similarity).
 METAL 51 51 Magnesium (By similarity).
 METAL 146 146 Magnesium (By similarity).
 METAL 148 148 Magnesium (By similarity).
 BINDING 36 36 Substrate (By similarity).
 BINDING 70 70 Substrate (By similarity).
 BINDING 74 74 Substrate (By similarity).
 BINDING 87 87 Substrate (By similarity).
 MOD_RES 176 176 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Cholesterol biosynthesis; Cholesterol metabolism; Complete proteome; Isomerase; Isoprene biosynthesis; Lipid biosynthesis; Lipid metabolism; Magnesium; Metal-binding; Peroxisome; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 227 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:RGD.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; TAS:RGD.
 GO:0000287; F:magnesium ion binding; IEA:Compara.
 GO:0030145; F:manganese ion binding; IEA:Compara.
 GO:0006695; P:cholesterol biosynthetic process; TAS:RGD.
 GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
 GO:0035634; P:response to stilbenoid; IEA:Compara. 

Interpro

 IPR011876; IsopentenylPP_isomerase_typ1.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX 

PRINTS