CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018596
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier organic anion transporter family member 1A5 
Protein Synonyms/Alias
 Organic anion-transporting polypeptide 3; OATP-3; Sodium-independent organic anion transporter 3; Solute carrier family 21 member 7 
Gene Name
 Slco1a5 
Gene Synonyms/Alias
 Oatp1a5; Oatp3; Slc21a7 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
667VENDGELKTKL****ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Mediates the Na(+)-independent transport of organic anions such as taurocholate and thyroid hormones (By similarity). 
Sequence Annotation
 DOMAIN 433 488 Kazal-like.
 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
 CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
 CARBOHYD 483 483 N-linked (GlcNAc...) (Potential).
 CARBOHYD 492 492 N-linked (GlcNAc...) (Potential).
 DISULFID 439 465 By similarity.
 DISULFID 443 454 By similarity.
 DISULFID 445 469 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 670 AA 
Protein Sequence
MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ FDIPTSIVGL 60
INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC FLMSLPHFLM GRYEYETTIS 120
PTSNLSSNSF LCMENRTQTL KPTQDPAECV KEMKSLMWIY VLVGNIIRGI GETPIMPLGI 180
SYIEDFAKSE NSPLYIGILE SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR 240
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG 300
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TSEVVLLIGV 360
CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL LSYFHFMISC DNFQVAGLTT 420
SYEGVQHPLY VENKVLADCN TRCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGMGTHMV 480
FQNCSCIQSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK 540
SEEKSLGIGL HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI 600
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE CTDVHGIPKV 660
ENDGELKTKL 670 
Gene Ontology
 GO:0031526; C:brush border membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; ISO:MGI.
 GO:0015125; F:bile acid transmembrane transporter activity; ISO:MGI.
 GO:0015349; F:thyroid hormone transmembrane transporter activity; IEA:Compara.
 GO:0050892; P:intestinal absorption; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara. 
Interpro
 IPR002350; Kazal_dom.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR004156; OA_transporter. 
Pfam
 PF07648; Kazal_2
 PF03137; OATP 
SMART
 SM00280; KAZAL 
PROSITE
 PS51465; KAZAL_2
 PS50850; MFS 
PRINTS