CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040973
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable E3 ubiquitin-protein ligase MYCBP2 
Protein Synonyms/Alias
  
Gene Name
 PAM 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
312EDVVHVHKYNPTEKAubiquitination[1]
318HKYNPTEKAESESDLubiquitination[1]
335EIANVVQKKDLGRSDubiquitination[1]
513FKLDPNNKEGPVLILubiquitination[1, 2]
803AFGDSEHKLETSSGRubiquitination[1]
818VLGRFRGKGSGGLNLubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 875 AA 
Protein Sequence
MDTVHHMLLF GCNMPSSTGS YWFCDEGTCT DKANILYAWA RNAPPTRLPK GVGFRVGGET 60
GSKYFVLQVH YGDISAFRDN NKDCSGVSLH LTRLPQPLIA GMYLMMSVDT VIPAGEKVVN 120
SDISCHYKNY PMHVFAYRVH THHLGKVVSG YRVRNGQWTL IGRQSPQLPQ AFYPVGHPVD 180
VSFGDLLAAR CVFTGEGRTE ATHIGGTSSD EMCNLYIMYY MEAKHAVSFM TCTQNVAPDM 240
FRTIPPEANI PIPVKSDMVM MHEHHKETEY KDKIPLLQQP KREEEEVLDQ GDFYSLLSKL 300
LGEREDVVHV HKYNPTEKAE SESDLVAEIA NVVQKKDLGR SDAREGAEHE RGNAILVRDR 360
IHKFHRLVST LRPPESRVFS LQQPPPGEGT WEPEHTGDFH MEEALDWPGV YLLPGQVSGV 420
ALDPKNNLVI FHRGDHVWDG NSFDSKFVYQ QIGLGPIEED TILVIDPNNA AVLQSSGKNL 480
FYLPHGLSID KDGNYWVTDV ALHQVFKLDP NNKEGPVLIL GRSMQPGSDQ NHFCQPTDVA 540
VDPGTGAIYV SDGYCNSRIV QFSPSGKFIT QWGEESSGSS PLPGQFTVPH SLALVPLLGQ 600
LCVADRENGR IQCFKTDTKE FVREIKHSSF GRNVFAISYI PGLLFAVNGK PHFGDQEPVQ 660
GFVMNFSNGE IIDIFKPVRK HFDMPHDIVA SEDGTVYIGD AHTNTVWKFT LTEKLEHRSV 720
KKAGIEVQEI KAEAVVETKM ENKPTSSELQ KMQEKQKLIK EPGSGVPVVL ITTLLVIPVV 780
VLLAIAIFIR WKKSRAFGDS EHKLETSSGR VLGRFRGKGS GGLNLGNFFA SRKGYSRKGF 840
DRLSTEGSDQ EKEDDGSESE EEYSAPLPAL APSSS 875 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004504; F:peptidylglycine monooxygenase activity; IEA:InterPro.
 GO:0006518; P:peptide metabolic process; IEA:InterPro. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR014784; Cu2_ascorb_mOase-like_C.
 IPR020611; Cu2_ascorb_mOase_CS-1.
 IPR014783; Cu2_ascorb_mOase_CS-2.
 IPR000323; Cu2_ascorb_mOase_N.
 IPR001258; NHL_repeat.
 IPR013017; NHL_repeat_subgr.
 IPR000720; Pep_amidat_mOase.
 IPR008977; PHM/PNGase_F_dom. 
Pfam
 PF01082; Cu2_monooxygen
 PF01436; NHL 
SMART
  
PROSITE
 PS00084; CU2_MONOOXYGENASE_1
 PS00085; CU2_MONOOXYGENASE_2
 PS51125; NHL 
PRINTS
 PR00790; PAMONOXGNASE.