CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002402
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcriptional activator Myb 
Protein Synonyms/Alias
 Proto-oncogene c-Myb 
Gene Name
 Myb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
438PCRDQTVKTQKENSIacetylation[1]
441DQTVKTQKENSIFRTacetylation[1]
Reference
 [1] Increased affinity of c-Myb for CREB-binding protein (CBP) after CBP-induced acetylation.
 Sano Y, Ishii S.
 J Biol Chem. 2001 Feb 2;276(5):3674-82. [PMID: 11073948] 
Functional Description
 Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 
Sequence Annotation
 DOMAIN 35 86 HTH myb-type 1.
 DOMAIN 87 142 HTH myb-type 2.
 DOMAIN 143 193 HTH myb-type 3.
 DNA_BIND 63 86 H-T-H motif (By similarity).
 DNA_BIND 115 138 H-T-H motif.
 DNA_BIND 166 189 H-T-H motif.
 REGION 90 193 Interaction with HIPK2 and NLK.
 REGION 275 327 Transcriptional activation domain (By
 REGION 328 460 Negative regulatory domain.
 REGION 375 396 Leucine-zipper.
 MOD_RES 467 467 N6-acetyllysine (By similarity).
 MOD_RES 476 476 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 636 AA 
Protein Sequence
MARRPRHSIY SSDEDDEDIE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT 60
DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK 120
HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA 180
IKNHWNSTMR RKVEQEGYLQ EPSKASQTPV ATSFQKNNHL MGFGHASPPS QLSPSGQSSV 240
NSEYPYYHIA EAQNISSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL 300
LLMSTENELK GQQALPTQNH TCSYPGWHST SIVDQTRPHG DSAPVSCLGE HHATPSLPAD 360
PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SFLNTSSNHE SSGLDAPTLP 420
STPLIGHKLT PCRDQTVKTQ KENSIFRTPA IKRSILESSP RTPTPFKHAL AAQEIKYGPL 480
KMLPQTPSHA VEDLQDVIKQ ESDESGIVAE FQESGPPLLK KIKQEVESPT EKSGNFFCSN 540
HWAENSLSTQ LFSQASPVAD APNILTSSVL MTPVSEDEDN VLKAFTVPKN RPLVGPLQPC 600
SGAWEPASCG KTEDQMTASG PARKYVNAFS ARTLVM 636 
Gene Ontology
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0030183; P:B cell differentiation; IMP:MGI.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0006338; P:chromatin remodeling; IEA:Compara.
 GO:0048566; P:embryonic digestive tract development; IMP:MGI.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
 GO:0048872; P:homeostasis of number of cells; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Compara.
 GO:0051574; P:positive regulation of histone H3-K9 methylation; IEA:Compara.
 GO:0045624; P:positive regulation of T-helper cell differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0048538; P:thymus development; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR015395; C-myb_C.
 IPR009057; Homeodomain-like.
 IPR017930; Myb_dom.
 IPR001005; SANT/Myb.
 IPR012642; Tscrpt_reg_Wos2-domain. 
Pfam
 PF09316; Cmyb_C
 PF07988; LMSTEN
 PF00249; Myb_DNA-binding 
SMART
 SM00717; SANT 
PROSITE
 PS51294; HTH_MYB 
PRINTS