UniProt Accession

 PPIL1_MOUSE; Q9D0W5; Q3UA03 

Genbank Protein ID

 AK004331; AK150643; AK151572; BC058369 

Genbank Nucleotide ID

 BAB23265.1; BAE29731.1; BAE30513.1; AAH58369.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase-like 1 

Protein Synonyms/Alias

 PPIase; Rotamase PPIL1 

Gene Name

 Ppil1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
37	KHAPKTCKNFAELAR	acetylation	[1]
58	TKFHRIIKDFMIQGG	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). 

Sequence Annotation

 DOMAIN 10 164 PPIase cyclophilin-type.
 REGION 54 65 Cyclosporin A binding (By similarity).
 REGION 70 71 Cyclosporin A binding (By similarity).
 REGION 99 104 Cyclosporin A binding (By similarity).
 REGION 109 113 Cyclosporin A binding (By similarity).
 BINDING 119 119 Cyclosporin A (By similarity).
 BINDING 125 125 Cyclosporin A (By similarity).  

Keyword

 Complete proteome; Isomerase; mRNA processing; mRNA splicing; Reference proteome; Rotamase; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 166 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR002130; Cyclophilin-like_PPIase_dom.
 IPR024936; Cyclophilin-type_PPIase.
 IPR020892; Cyclophilin-type_PPIase_CS. 

Pfam

 PF00160; Pro_isomerase 

SMART

  

PROSITE

 PS00170; CSA_PPIASE_1
 PS50072; CSA_PPIASE_2 

PRINTS

 PR00153; CSAPPISMRASE.