| Tag | Content |
|---|
| CPLM ID | CPLM-023095 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | POU domain, class 2, transcription factor 3 |
Protein Synonyms/Alias | Octamer-binding protein 11; Oct-11; Octamer-binding transcription factor 11; OTF-11; Transcription factor PLA-1; Transcription factor Skn-1 |
Gene Name | POU2F3 |
Gene Synonyms/Alias | OTF11; PLA1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 200 | TFKQRRIKLGFTQGD | ubiquitination | [1] | | 214 | DVGLAMGKLYGNDFS | ubiquitination | [1] | | 236 | EALNLSFKNMCKLKP | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lactogen. |
Sequence Annotation | DOMAIN 183 257 POU-specific.
DNA_BIND 281 340 Homeobox. |
Keyword | Alternative splicing; Complete proteome; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 436 AA |
Protein Sequence | MNDAKDIKMS GDVADSTDAR STLSQVEPGN DRNGLDFNRQ IKTEDLSDSL QQTLSHRPCH 60
LSQGPAMMSG NQMSGLNASP CQDMASLHPL QQLVLVPGHL QSVSQFLLSQ TQPGQQGLQP 120
NLLPFPQQQS GLLLPQTGPG LASQAFGHPG LPGSSLEPHL EASQHLPVPK HLPSSGGADE 180
PSDLEELEKF AKTFKQRRIK LGFTQGDVGL AMGKLYGNDF SQTTISRFEA LNLSFKNMCK 240
LKPLLEKWLN DAESSPSDPS VSTPSSYPSL SEVFGRKRKK RTSIETNIRL TLEKRFQDNP 300
KPSSEEISMI AEQLSMEKEV VRVWFCNRRQ KEKRINCPVA TPIKPPVYNS RLVSPSGSLG 360
PLSVPPVHST MPGTVTSSCS PGNNSRPSSP GSGLHASSPT ASQNNSKAAV NSASSFNSSG 420
SWYRWNHSTY LH 432 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0005667; C:transcription factor complex; IEA:Compara. GO:0043565; F:sequence-specific DNA binding; IDA:MGI. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008544; P:epidermis development; TAS:ProtInc. GO:0030216; P:keratinocyte differentiation; IEA:Compara. GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0042060; P:wound healing; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |