CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008849
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PMS1 protein homolog 1 
Protein Synonyms/Alias
 DNA mismatch repair protein PMS1 
Gene Name
 PMS1 
Gene Synonyms/Alias
 PMSL1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKQLPAATVubiquitination[1]
43GATSVDVKLENYGFDubiquitination[2]
51LENYGFDKIEVRDNGubiquitination[1]
62RDNGEGIKAVDAPVMubiquitination[1]
72DAPVMAMKYYTSKINubiquitination[1]
77AMKYYTSKINSHEDLubiquitination[1]
150VTALRLFKNLPVRKQubiquitination[1]
362AADIVLSKTAETDVLubiquitination[2]
372ETDVLFNKVESSGKNubiquitination[1]
688LLQSQIEKRRSQNIKubiquitination[2]
894QLPMYLSKEDIQDIIacetylation[3]
894QLPMYLSKEDIQDIIubiquitination[2]
905QDIIYRMKHQFGNEIacetylation[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Probably involved in the repair of mismatches in DNA. 
Sequence Annotation
 DNA_BIND 571 639 HMG box.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; DNA damage; DNA repair; DNA-binding; Hereditary nonpolyposis colorectal cancer; Nucleus; Polymorphism; Reference proteome; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 932 AA 
Protein Sequence
MKQLPAATVR LLSSSQIITS VVSVVKELIE NSLDAGATSV DVKLENYGFD KIEVRDNGEG 60
IKAVDAPVMA MKYYTSKINS HEDLENLTTY GFRGEALGSI CCIAEVLITT RTAADNFSTQ 120
YVLDGSGHIL SQKPSHLGQG TTVTALRLFK NLPVRKQFYS TAKKCKDEIK KIQDLLMSFG 180
ILKPDLRIVF VHNKAVIWQK SRVSDHKMAL MSVLGTAVMN NMESFQYHSE ESQIYLSGFL 240
PKCDADHSFT SLSTPERSFI FINSRPVHQK DILKLIRHHY NLKCLKESTR LYPVFFLKID 300
VPTADVDVNL TPDKSQVLLQ NKESVLIALE NLMTTCYGPL PSTNSYENNK TDVSAADIVL 360
SKTAETDVLF NKVESSGKNY SNVDTSVIPF QNDMHNDESG KNTDDCLNHQ ISIGDFGYGH 420
CSSEISNIDK NTKNAFQDIS MSNVSWENSQ TEYSKTCFIS SVKHTQSENG NKDHIDESGE 480
NEEEAGLENS SEISADEWSR GNILKNSVGE NIEPVKILVP EKSLPCKVSN NNYPIPEQMN 540
LNEDSCNKKS NVIDNKSGKV TAYDLLSNRV IKKPMSASAL FVQDHRPQFL IENPKTSLED 600
ATLQIEELWK TLSEEEKLKY EEKATKDLER YNSQMKRAIE QESQMSLKDG RKKIKPTSAW 660
NLAQKHKLKT SLSNQPKLDE LLQSQIEKRR SQNIKMVQIP FSMKNLKINF KKQNKVDLEE 720
KDEPCLIHNL RFPDAWLMTS KTEVMLLNPY RVEEALLFKR LLENHKLPAE PLEKPIMLTE 780
SLFNGSHYLD VLYKMTADDQ RYSGSTYLSD PRLTANGFKI KLIPGVSITE NYLEIEGMAN 840
CLPFYGVADL KEILNAILNR NAKEVYECRP RKVISYLEGE AVRLSRQLPM YLSKEDIQDI 900
IYRMKHQFGN EIKECVHGRP FFHHLTYLPE TT 932 
Gene Ontology
 GO:0032389; C:MutLalpha complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0016887; F:ATPase activity; IBA:RefGenome.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0032407; F:MutSalpha complex binding; IBA:RefGenome.
 GO:0003697; F:single-stranded DNA binding; IBA:RefGenome.
 GO:0006298; P:mismatch repair; IBA:RefGenome.
 GO:0007131; P:reciprocal meiotic recombination; IBA:RefGenome. 
Interpro
 IPR002099; DNA_mismatch_repair.
 IPR013507; DNA_mismatch_repair_C.
 IPR014762; DNA_mismatch_repair_CS.
 IPR014763; DNA_mismatch_repair_N.
 IPR003594; HATPase_ATP-bd.
 IPR009071; HMG_box_dom.
 IPR020568; Ribosomal_S5_D2-typ_fold.
 IPR014721; Ribosomal_S5_D2-typ_fold_subgr. 
Pfam
 PF01119; DNA_mis_repair
 PF02518; HATPase_c
 PF00505; HMG_box 
SMART
 SM00387; HATPase_c
 SM00398; HMG 
PROSITE
 PS00058; DNA_MISMATCH_REPAIR_1
 PS50118; HMG_BOX_2 
PRINTS