UniProt Accession

 MOBB_ECOLI; P32125; P76770; Q2M8F4 

Genbank Protein ID

 L19201; U00096; AP009048 

Genbank Nucleotide ID

 AAB02991.1; AAC76854.2; BAE77452.1 

Protein Name

 Molybdopterin-guanine dinucleotide biosynthesis adapter protein 

Protein Synonyms/Alias

 MGD biosynthesis adapter protein; Molybdenum cofactor biosynthesis adapter protein; Moco biosynthesis adapter protein; Molybdopterin-guanine dinucleotide biosynthesis protein B 

Gene Name

 mobB 

Gene Synonyms/Alias

 yihC; b3856; JW5575 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
52	HHDMDVDKPGKDSYE	acetylation	[1]
55	MDVDKPGKDSYELRK	acetylation	[1]
111	LILVEGFKHEEIAKI	acetylation	[1]
117	FKHEEIAKIVLFRDG	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity. Is also able to bind the nucleotides ATP, TTP and GDP, but with lower affinity than GTP. 

Sequence Annotation

 NP_BIND 17 21 GTP (Probable).
 NP_BIND 51 54 GTP (Potential).
 NP_BIND 100 103 GTP (Potential).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; GTP-binding; Molybdenum cofactor biosynthesis; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR004435; MobB_cons_dom.
 IPR027417; P-loop_NTPase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS