CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023452
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable UDP-glucose 4-epimerase 
Protein Synonyms/Alias
 Galactowaldenase; UDP-galactose 4-epimerase 
Gene Name
 Gale 
Gene Synonyms/Alias
 CG12030 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
162TSPYGKTKYFTEEILacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine (By similarity). 
Sequence Annotation
 NP_BIND 5 36 NAD (By similarity).
 ACT_SITE 158 158 Proton acceptor (By similarity).
 BINDING 133 133 Substrate (By similarity).  
Keyword
 Carbohydrate metabolism; Complete proteome; Galactose metabolism; Isomerase; NAD; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 350 AA 
Protein Sequence
MAPPTVLVTG GAGYIGSHTV LEMLNAGYNV ICVDNLCNAY SSGAKLPEAL SRVQEITGKK 60
VNFYRVDITD REQVRSVFQE HKIDMVAHFA ALKAVGESCR IPLQYYHNNM TGTNVLLEAM 120
ADNNVFKFVY SSSATVYGEP KFLPVTEEHP TGNCTSPYGK TKYFTEEILK DLCKSDKRWA 180
VVSLRYFNPV GAHISGRIGE DPNGEPNNLM PYIAQVAVGR RPSLSVYGSD FPTHDGTGVR 240
DYIHIVDLAE GHVKALDKLR NIAETGFFAY NLGTGVGYSV LDMVKAFEKA SGKKVNYTLV 300
DRRSGDVATC YADATLADKK LGWKAERGID KMCEDTWRWQ SQNPNGYANK 350 
Gene Ontology
 GO:0050662; F:coenzyme binding; IEA:InterPro.
 GO:0003978; F:UDP-glucose 4-epimerase activity; IMP:FlyBase.
 GO:0044237; P:cellular metabolic process; IEA:InterPro.
 GO:0006012; P:galactose metabolic process; IMP:FlyBase. 
Interpro
 IPR025308; Epimerase_C.
 IPR001509; Epimerase_deHydtase.
 IPR005886; GalE.
 IPR016040; NAD(P)-bd_dom.
 IPR008089; Nuc_sugar_epim. 
Pfam
 PF01370; Epimerase
 PF13950; Epimerase_Csub 
SMART
  
PROSITE
  
PRINTS
 PR01713; NUCEPIMERASE.