UniProt Accession

 CHMP5_MOUSE; Q9D7S9; Q3UI64 

Genbank Protein ID

 AK008911; AK147058; BC006947 

Genbank Nucleotide ID

 BAB25962.1; BAE27642.1; AAH06947.1 

Protein Name

 Charged multivesicular body protein 5 

Protein Synonyms/Alias

 Chromatin-modifying protein 5; SNF7 domain-containing protein 2 

Gene Name

 Chmp5 

Gene Synonyms/Alias

 Snf7dc2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
44	RLDAELVKYKDQIKK	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). 

Sequence Annotation

 MOD_RES 219 219 Phosphoserine (By similarity).  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 219 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0008333; P:endosome to lysosome transport; IMP:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0001919; P:regulation of receptor recycling; IMP:MGI. 

Interpro

 IPR005024; Snf7. 

Pfam

 PF03357; Snf7 

SMART

  

PROSITE

  

PRINTS