CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013729
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60 kDa chaperonin 
Protein Synonyms/Alias
 GroEL protein; Protein Cpn60 
Gene Name
 groL 
Gene Synonyms/Alias
 groEL; GK0249 
Created Date
 July 27, 2013 
Organism
 Geobacillus kaustophilus (strain HTA426) 
NCBI Taxa ID
 235909 
Lysine Modification
Position
Peptide
Type
References
57NDGVTIAKEIELEDPacetylation[1]
140ISKPIKGKESIAQVAacetylation[1]
223PYILITDKKVSSIQEacetylation[1]
284PGFGDRRKAMLEDIAacetylation[1]
320ASLGRAAKVVVTKETacetylation[1]
521TEAVVADKPEENKGNacetylation[1]
Reference
 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 538 AA 
Protein Sequence
MAKQIKFSEE ARRAMLRGVD KLADAVKVTL GPKGRNVVLE KKFGSPLITN DGVTIAKEIE 60
LEDPFENMGA KLVAEVASKT NDIAGDGTTT ATVLAQAMIR EGLKNVAAGA NPMGIRRGIE 120
KAVAVAVEEL KAISKPIKGK ESIAQVAAIS AADEEVGQLI AEAMERVGND GVITLEESKG 180
FTTELDVVEG MQFDRGYVSP YMITDTEKME AVLENPYILI TDKKVSSIQE LLPVLEQVVQ 240
QGRPLLIIAE DVEGEALATL VVNKLRGTFN AVAVKAPGFG DRRKAMLEDI AILTGGEVIS 300
EELGRELKST TIASLGRAAK VVVTKETTTI VEGAGDSERI KARINQIRAQ LEETTSEFDR 360
EKLQERLAKL AGGVAVIKVG AATETELKER KLRIEDALNS TRAAVEEGIV AGGGTALMNI 420
YNKVAAIEAE GDEATGVKIV LRAIEEPVRQ IAQNAGLEGS IIVERLKNEK PGIGFNAATG 480
EWVDMIEAGI VDPTKVTRSA LQNAASVAAM VLTTEAVVAD KPEENKGNNN MPDMGGMM 538 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0042026; P:protein refolding; IEA:HAMAP. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.