UniProt Accession

 AMRP_HUMAN; P30533; D3DVR9; Q2M310; Q53HQ3; Q53HS6 

Genbank Protein ID

 M63959; AF035767; AF035760; AF035761; AF035762; AF035763; AF035764; AF035765; AF035766; AK222504; AK222527; AL590235; CH471131; CH471131; BC105074; BC112067; U06976 

Genbank Nucleotide ID

 AAA51553.1; AAC67373.1; AAC67373.1; AAC67373.1; AAC67373.1; AAC67373.1; AAC67373.1; AAC67373.1; AAC67373.1; BAD96224.1; BAD96247.1; CAM21451.1; EAW82460.1; EAW82461.1; AAI05075.1; AAI12068.1; AAA87889.1 

Protein Name

 Alpha-2-macroglobulin receptor-associated protein 

Protein Synonyms/Alias

 Alpha-2-MRAP; Low density lipoprotein receptor-related protein-associated protein 1; RAP 

Gene Name

 LRPAP1 

Gene Synonyms/Alias

 A2MRAP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
287	ELKHFEAKIEKHNHY	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. 

Sequence Annotation

 REGION 237 353 LDL receptor binding (Potential).
 MOTIF 354 357 Prevents secretion from ER (Potential).
 CARBOHYD 268 268 N-linked (GlcNAc...).  

Keyword

 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Heparin-binding; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005576; C:extracellular region; IDA:GOC.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0048237; C:rough endoplasmic reticulum lumen; IEA:Compara.
 GO:0031982; C:vesicle; IEA:Compara.
 GO:0004873; F:asialoglycoprotein receptor activity; TAS:ProtInc.
 GO:0008201; F:heparin binding; TAS:ProtInc.
 GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:MGI.
 GO:0048019; F:receptor antagonist activity; IDA:BHF-UCL.
 GO:0051082; F:unfolded protein binding; TAS:ProtInc.
 GO:1900222; P:negative regulation of beta-amyloid clearance; IGI:BHF-UCL.
 GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.
 GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0006457; P:protein folding; TAS:ProtInc. 

Interpro

 IPR010483; Alpha_2_MRAP_C.
 IPR009066; MG_RAP_rcpt_1. 

Pfam

 PF06401; Alpha-2-MRAP_C
 PF06400; Alpha-2-MRAP_N 

SMART

  

PROSITE

 PS00014; ER_TARGET 

PRINTS