UniProt Accession

 RPR1A_HUMAN; Q96P16; A8KA42; B2RBA3; Q7Z5G8; Q96FY9; Q9NVL4 

Genbank Protein ID

 AF419845; AK001518; AK292907; AK314569; CH471088; CH471088; CH471088; BC000225; BC010136 

Genbank Nucleotide ID

 AAL15972.1; BAA91736.1; BAF85596.1; BAG37150.1; EAX01365.1; EAX01366.1; EAX01367.1; AAH00225.2; AAH10136.1 

Protein Name

 Regulation of nuclear pre-mRNA domain-containing protein 1A 

Protein Synonyms/Alias

 Cyclin-dependent kinase inhibitor 2B-related protein; p15INK4B-related protein 

Gene Name

 RPRD1A 

Gene Synonyms/Alias

 P15RS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	SEAALEKKLSELSNS	ubiquitination	[1]
126	NDVLEQLKQALYGDK	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. 

Sequence Annotation

 DOMAIN 2 133 CID.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; IDA:UniProtKB.
 GO:0070940; P:dephosphorylation of RNA polymerase II C-terminal domain; IMP:UniProtKB. 

Interpro

 IPR006569; CID_dom.
 IPR008942; ENTH_VHS.
 IPR006903; RNA_pol_II-bd. 

Pfam

 PF04818; CTD_bind 

SMART

 SM00582; RPR 

PROSITE

 PS51391; CID 

PRINTS