UniProt Accession

 PFD5_MOUSE; Q9WU28; Q3UKS8; Q9JMJ8 

Genbank Protein ID

 AF108357; AB011473; AK028206; AK145883; BC026920 

Genbank Nucleotide ID

 AAD28373.1; BAA92269.1; BAC25814.1; BAE26723.1; AAH26920.1 

Protein Name

 Prefoldin subunit 5 

Protein Synonyms/Alias

 C-Myc-binding protein Mm-1; EIG-1; Myc modulator 1 

Gene Name

 Pfdn5 

Gene Synonyms/Alias

 Eig1; Mm1; Pfd5 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	DCLNVLNKSNEGKEL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 42 42 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chaperone; Complete proteome; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0060041; P:retina development in camera-type eye; IMP:MGI. 

Interpro

 IPR011599; PFD_alpha.
 IPR027236; PFDN5.
 IPR009053; Prefoldin.
 IPR004127; Prefoldin_subunit. 

Pfam

 PF02996; Prefoldin 

SMART

  

PROSITE

  

PRINTS