| Tag | Content |
|---|
| CPLM ID | CPLM-024105 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 3'(2'),5'-bisphosphate nucleotidase 1 |
Protein Synonyms/Alias | Bisphosphate 3'-nucleotidase 1; PAP-inositol 1,4-phosphatase; PIP; scHAL2 analogous 3 |
Gene Name | Bpnt1 |
Gene Synonyms/Alias | Sal3 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | SATDLQTKADRMVQM | acetylation | [1] | | 274 | GNPLQYDKEVKHMNS | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. |
Sequence Annotation | REGION 119 122 Substrate binding.
REGION 195 198 Substrate binding.
REGION 220 224 Substrate.
METAL 74 74 Magnesium 1.
METAL 117 117 Magnesium 1.
METAL 117 117 Magnesium 2.
METAL 119 119 Magnesium 1; via carbonyl oxygen.
METAL 120 120 Magnesium 2.
METAL 247 247 Magnesium 2.
BINDING 74 74 Substrate (By similarity).
BINDING 242 242 Substrate; via carbonyl oxygen.
BINDING 247 247 Substrate.
MOD_RES 2 2 N-acetylalanine. |
Keyword | 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Hydrolase; Lithium; Magnesium; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 308 AA |
Protein Sequence | MASSHNVLMR LVASAYSIAQ KAGTIVRCVI AEGDLGIVQK TSATDLQTKA DRMVQMSICS 60
SLSRKFPKLT IIGEEDLPPG EVDQELIEDG QSEEILKQPC PSQYSAIKEE DLVVWVDPVD 120
GTKEYTEGLL DNVTVLIGIA YEGKAIAGII NQPYYNYQAG PDAVLGRTIW GVLGLGAFGF 180
QLKEAPAGKH IITTTRSHSN KLVTDCIAAM NPDNVLRVGG AGNKIIQLIE GKASAYVFAS 240
PGCKKWDTCA PEVILHAVGG KLTDIHGNPL QYDKEVKHMN SAGVLAALRN YEYYASRVPE 300
SVKSALIP 308 |
Gene Ontology | GO:0008441; F:3'(2'),5'-bisphosphate nucleotidase activity; IDA:RGD. GO:0004441; F:inositol-1,4-bisphosphate 1-phosphatase activity; IDA:RGD. GO:0000287; F:magnesium ion binding; IDA:RGD. GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |