| Tag | Content |
|---|
| CPLM ID | CPLM-011361 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Importin subunit beta-1 |
Protein Synonyms/Alias | Importin-95; Karyopherin subunit beta-1; Karyopherin-95 |
Gene Name | KAP95 |
Gene Synonyms/Alias | YLR347C; L8300.15 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 76 | LVSKDSVKTQQFAQR | ubiquitination | [1] | | 93 | TQVSPEAKNQIKTNA | ubiquitination | [1] | | 152 | AEQPENVKRASLLAL | ubiquitination | [1] | | 213 | ADSLIFIKNNMEREG | ubiquitination | [1] | | 845 | QLFSQATKDTARWAR | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of histones H2A and H2B. |
Sequence Annotation | DOMAIN 25 106 Importin N-terminal.
REPEAT 130 168 HEAT 1.
REPEAT 220 257 HEAT 2.
REPEAT 320 364 HEAT 3.
REPEAT 366 402 HEAT 4.
REPEAT 407 444 HEAT 5.
REPEAT 571 608 HEAT 6.
REPEAT 635 672 HEAT 7.
REPEAT 676 715 HEAT 8.
REGION 332 345 IAB.
REGION 337 422 Ran-GTP binding (By similarity).
MOD_RES 836 836 Phosphoserine. |
Keyword | 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 861 AA |
Protein Sequence | MSTAEFAQLL ENSILSPDQN IRLTSETQLK KLSNDNFLQF AGLSSQVLID ENTKLEGRIL 60
AALTLKNELV SKDSVKTQQF AQRWITQVSP EAKNQIKTNA LTALVSIEPR IANAAAQLIA 120
AIADIELPHG AWPELMKIMV DNTGAEQPEN VKRASLLALG YMCESADPQS QALVSSSNNI 180
LIAIVQGAQS TETSKAVRLA ALNALADSLI FIKNNMEREG ERNYLMQVVC EATQAEDIEV 240
QAAAFGCLCK IMSLYYTFMK PYMEQALYAL TIATMKSPND KVASMTVEFW STICEEEIDI 300
AYELAQFPQS PLQSYNFALS SIKDVVPNLL NLLTRQNEDP EDDDWNVSMS AGACLQLFAQ 360
NCGNHILEPV LEFVEQNITA DNWRNREAAV MAFGSIMDGP DKVQRTYYVH QALPSILNLM 420
NDQSLQVKET TAWCIGRIAD SVAESIDPQQ HLPGVVQACL IGLQDHPKVA TNCSWTIINL 480
VEQLAEATPS PIYNFYPALV DGLIGAANRI DNEFNARASA FSALTTMVEY ATDTVAETSA 540
SISTFVMDKL GQTMSVDENQ LTLEDAQSLQ ELQSNILTVL AAVIRKSPSS VEPVADMLMG 600
LFFRLLEKKD SAFIEDDVFY AISALAASLG KGFEKYLETF SPYLLKALNQ VDSPVSITAV 660
GFIADISNSL EEDFRRYSDA MMNVLAQMIS NPNARRELKP AVLSVFGDIA SNIGADFIPY 720
LNDIMALCVA AQNTKPENGT LEALDYQIKV LEAVLDAYVG IVAGLHDKPE ALFPYVGTIF 780
QFIAQVAEDP QLYSEDATSR AAVGLIGDIA AMFPDGSIKQ FYGQDWVIDY IKRTRSGQLF 840
SQATKDTARW AREQQKRQLS L 861 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005643; C:nuclear pore; IDA:SGD. GO:0008565; F:protein transporter activity; IDA:SGD. GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; IDA:SGD. GO:0051292; P:nuclear pore complex assembly; IMP:SGD. GO:0006656; P:phosphatidylcholine biosynthetic process; IMP:SGD. GO:0006606; P:protein import into nucleus; IMP:SGD. GO:0006612; P:protein targeting to membrane; IMP:SGD. GO:0060188; P:regulation of protein desumoylation; IMP:SGD. |
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Pfam | |
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PROSITE | |
PRINTS | |