UniProt Accession

 CECR1_HUMAN; Q9NZK5; A8K9H4; Q6ICF1; Q86UB6; Q8NCJ2; Q96K41 

Genbank Protein ID

 AF190746; CR456417; AK027682; AK292689; AK074702; AC005300; CH471193; BC051755 

Genbank Nucleotide ID

 AAF65941.1; CAG30303.1; BAB55293.1; BAF85378.1; BAC11148.1; EAW57750.1; AAH51755.1 

Protein Name

 Adenosine deaminase CECR1 

Protein Synonyms/Alias

 Cat eye syndrome critical region protein 1 

Gene Name

 CECR1 

Gene Synonyms/Alias

 ADA2; ADGF; IDGFL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
40	TRAHLLLKEKMMRLG	ubiquitination	[1]
55	GRLVLNTKEELANER	ubiquitination	[1]
67	NERLMTLKIAEMKEA	ubiquitination	[1]
72	TLKIAEMKEAMRTLI	ubiquitination	[1]
158	PTPRPSEKCSKWILL	ubiquitination	[1]
161	RPSEKCSKWILLEDY	ubiquitination	[1]
267	HDEEWSVKTYQEVAQ	ubiquitination	[1]
275	TYQEVAQKFVETHPE	ubiquitination	[1]
287	HPEFIGIKIIYSDHR	ubiquitination	[1]
296	IYSDHRSKDVAVIAE	ubiquitination	[1]
346	EALMIPAKDGVKLPY	ubiquitination	[1]
350	IPAKDGVKLPYFFHA	ubiquitination	[1]
390	GHGFALSKHPAVRTY	ubiquitination	[1]
401	VRTYSWKKDIPIEVC	ubiquitination	[1]
416	PISNQVLKLVSDLRN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity. 

Sequence Annotation

 REGION 30 100 Dimerization.
 REGION 127 185 PRB domain.
 REGION 204 211 Substrate binding.
 ACT_SITE 359 359 Proton donor (Probable).
 ACT_SITE 384 384 Proton acceptor (Probable).
 METAL 112 112 Zinc; catalytic.
 METAL 114 114 Zinc; catalytic.
 METAL 356 356 Zinc; catalytic.
 METAL 441 441 Zinc; catalytic.
 BINDING 115 115 Substrate.
 BINDING 293 293 Substrate.
 BINDING 326 326 Substrate; via amide nitrogen.
 BINDING 442 442 Substrate.
 CARBOHYD 127 127 N-linked (GlcNAc...).
 CARBOHYD 174 174 N-linked (GlcNAc...).
 CARBOHYD 185 185 N-linked (GlcNAc...).
 CARBOHYD 378 378 N-linked (GlcNAc...).
 DISULFID 137 159  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Heparin-binding; Hydrolase; Metal-binding; Polymorphism; Reference proteome; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 511 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0004000; F:adenosine deaminase activity; IDA:UniProtKB.
 GO:0031685; F:adenosine receptor binding; IDA:UniProtKB.
 GO:0008083; F:growth factor activity; NAS:UniProtKB.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0043394; F:proteoglycan binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IDA:UniProtKB.
 GO:0006154; P:adenosine catabolic process; IDA:UniProtKB.
 GO:0043103; P:hypoxanthine salvage; IBA:RefGenome.
 GO:0046103; P:inosine biosynthetic process; IBA:RefGenome.
 GO:0007275; P:multicellular organismal development; NAS:UniProtKB.
 GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro. 

Interpro

 IPR001365; A/AMP_deaminase_dom.
 IPR013659; A_deaminase_N.
 IPR006331; Ad_deam-like. 

Pfam

 PF00962; A_deaminase
 PF08451; A_deaminase_N 

SMART

  

PROSITE

 PS00485; A_DEAMINASE 

PRINTS