CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014981
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Melanoma-associated antigen D1 
Protein Synonyms/Alias
 MAGE-D1 antigen 
Gene Name
 MAGED1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Sus scrofa (Pig) 
NCBI Taxa ID
 9823 
Lysine Modification
Position
Peptide
Type
References
528RACFVLEKKFGIQLKubiquitination[1]
529ACFVLEKKFGIQLKEubiquitination[1]
619LLTYEFVKQKYLDYRubiquitination[1]
621TYEFVKQKYLDYRRVubiquitination[1]
662RFIAEVQKRDPRDWTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Binds NGFR/p75NTR and antagonizes its association with NTRK1/TrkA, inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members (By similarity). May enhance ubiquitin ligase activity of RING-type zinc finger- containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. 
Sequence Annotation
 REPEAT 302 307 1.
 REPEAT 308 313 2.
 REPEAT 314 319 3.
 REPEAT 338 343 4.
 REPEAT 344 349 5.
 REPEAT 350 355 6.
 REPEAT 356 361 7.
 REPEAT 362 367 8.
 REPEAT 368 373 9.
 REPEAT 374 379 10.
 REPEAT 380 385 11.
 REPEAT 386 391 12.
 REPEAT 392 397 13.
 REPEAT 398 403 14.
 REPEAT 404 409 15.
 REPEAT 410 415 16.
 REPEAT 416 421 17.
 REPEAT 422 427 18.
 REPEAT 428 433 19.
 REPEAT 434 438 20; approximate.
 REPEAT 439 444 21.
 REPEAT 445 450 22.
 DOMAIN 477 675 MAGE.
 REGION 302 450 22 X 6 AA tandem repeats of W-[PQ]-X-P-X-
 MOD_RES 97 97 Phosphotyrosine (By similarity).  
Keyword
 Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome; Repeat; Tumor antigen; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 784 AA 
Protein Sequence
MAQKMDCGAG LLGFQAEASV EDSTLLMQTL MEAIQISEAP PTNQATAAAS GPNASPQSSQ 60
PPSANEVADI QALAAATKPK TAFKAQNATT KGPNAAYDFS QALNAKEIPS TPPTVAFKAP 120
NAPSKGPNAA YDFSQAATTS ELTAKPEMAF KAQNATTKVG PNATYNFSPS LNANEMVNTQ 180
PKTAFKAWND TTKAPTAETQ TQNINQAKMA TSQADIEADP GPGICESDGA AAQTSADGSQ 240
AQNLESRTII RGKRTRKINN LNVEESSSGD QRRAPLAPGT WRSAPVPITT QSPPGAPPNV 300
LWQTPLAWQN PSGWQNQPAR QTPPARQSPP ARQTPPAWQN PVAWQNPVIW PNPVIWQNPV 360
IWPNPIVWPG PVVWPNPLAW QNPPGWQTPP GWQTPPGWQG PPDWQGPPDW PLPPDWPLPP 420
DWPLPTDWPL PPDWIPTDWP VPPDWQNLRP SPNLRPSPNS RASQNLGASQ PRDVALLQER 480
ANKLVKYLML KDYTKVPIKR SEMLRDIIRE YTDVYPEIIE RACFVLEKKF GIQLKEIDKE 540
EHLYILISTP ESLAGILGTT KDTPKLGLLL VILGVIFMNG NRASEAVLWE ALRKMGLRPG 600
VRHPLLGDLR KLLTYEFVKQ KYLDYRRVPN SNPPEYEFLW GLRSYHETSK MKVLRFIAEV 660
QKRDPRDWTA QFMEAADEAL DALDAAAAEA EARAEARTRM GIGDEAVSGP WSWDDIEFEL 720
LTWDEEGDFG DPWSRIPFTF WARYHQNARS RFPQTFAGPI IGPGGTASAN FAANFGAIGF 780
FWVE 784 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IEA:Compara.
 GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEA:Compara. 
Interpro
 IPR002190; MAGE. 
Pfam
 PF01454; MAGE 
SMART
  
PROSITE
 PS50838; MAGE 
PRINTS