Tag | Content |
---|
CPLM ID | CPLM-019980 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | LIM and SH3 domain protein 1 |
Protein Synonyms/Alias | LASP-1 |
Gene Name | Lasp1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
---|
23 | EKVNCLDKFWHKACF | acetylation | [1] | 42 | CKMTLNMKNYKGYEK | acetylation | [1] | 87 | LQSQVRYKEEFEKNK | acetylation | [1] | 96 | EFEKNKGKGFSVVAD | acetylation | [1] | 121 | QDQISNIKYHEEFEK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types. |
Sequence Annotation | DOMAIN 3 63 LIM zinc-binding. REPEAT 64 95 Nebulin 1. REPEAT 97 131 Nebulin 2. DOMAIN 204 263 SH3. MOD_RES 1 1 N-acetylmethionine (By similarity). MOD_RES 42 42 N6-acetyllysine (By similarity). MOD_RES 68 68 Phosphothreonine (By similarity). MOD_RES 104 104 Phosphothreonine (By similarity). MOD_RES 118 118 Phosphoserine (By similarity). MOD_RES 156 156 Phosphothreonine (By similarity). |
Keyword | Acetylation; Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Ion transport; LIM domain; Metal-binding; Phosphoprotein; Reference proteome; Repeat; SH3 domain; Transport; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 263 AA |
Protein Sequence | MNPNCARCGK IVYPTEKVNC LDKFWHKACF HCETCKMTLN MKNYKGYEKK PYCNAHYPKQ 60 SFTMVADTPE NLRLKQQSEL QSQVRYKEEF EKNKGKGFSV VADTPELQRI KKTQDQISNI 120 KYHEEFEKSR MGPSGGEGIE PERREAQDSS SYRRPTEQQQ PQPHHIPTSA PVYQQPQQQQ 180 VTPSYGGYKE PAAPVSIQRS APGGGGKRYR AVYDYSAADE DEVSFQDGDT IVNVQQIDDG 240 WMYGTVERTG DTGMLPANYV EAI 263 |
Gene Ontology | GO:0030864; C:cortical actin cytoskeleton; IDA:UniProtKB. GO:0005925; C:focal adhesion; IEA:Compara. GO:0015075; F:ion transmembrane transporter activity; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |