CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022842
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copine-7 
Protein Synonyms/Alias
 Copine VII 
Gene Name
 CPNE7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
174DDKDLFSKSDPFLELubiquitination[1]
419NVAPIISKVARVAAAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity). 
Sequence Annotation
 DOMAIN 28 114 C2 1.
 DOMAIN 237 321 C2 2.
 DOMAIN 382 581 VWFA.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 633 AA 
Protein Sequence
MSAGSERGAA ATPGGLPAPC ASKVELRLSC RHLLDRDPLT KSDPSVALLQ QAQGQWVQVG 60
RTEVVRSSLH PVFSKVFTVD YYFEEVQRLR FEVYDTHGPS GFSCQEDDFL GGMECTLGQI 120
VAQKKVTRPL LLKFGRNAGK STITVIAEDI SGNNGYVELS FRARKLDDKD LFSKSDPFLE 180
LYRVNDDQGL QLVYRTEVVK NNLNPVWEAF KVSLSSLCSC EETRPLKCLV WDYDSRGKHD 240
FIGEFSTTFE EMQKAFEEGQ AQWDCVNPKY KQKRRSYKNS GVVVLADLKF HRVYSFLDYI 300
MGGCQIHFTV AIDFTASNGD PRNSCSLHYI NPYQPNEYLK ALVSVGEICQ DYDSDKRFSA 360
LGFGARIPPK YEVSHDFAIN FNPEDDECEG IQGVVEAYQN CLPRVQLYGP TNVAPIISKV 420
ARVAAAEEST GKASQYYILL ILTDGVVTDM ADTREAIVRA SRLPMSIIIV GVGNADFTDM 480
QVLDGDDGVL RSPRGEPALR DIVQFVPFRE LKNASPAALA KCVLAEVPKQ VVEYYSHRGL 540
PPRSLGVPAG EASPGCTP 558 
Gene Ontology
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR010734; Copine.
 IPR002035; VWF_A. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2
 SM00327; VWA 
PROSITE
 PS50004; C2
 PS50234; VWFA 
PRINTS