UniProt Accession

 APC16_HUMAN; Q96DE5 

Genbank Protein ID

 AL607035; BC009530 

Genbank Nucleotide ID

 CAI15909.1; AAH09530.1 

Protein Name

 Anaphase-promoting complex subunit 16 

Protein Synonyms/Alias

 APC16; Cyclosome subunit 16 

Gene Name

 ANAPC16 

Gene Synonyms/Alias

 C10orf104 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
33	SDLAPPRKALFTYPK	ubiquitination	[1]
40	KALFTYPKGAGEMLE	ubiquitination	[1, 2]
68	YQVASTLKQVKHDQQ	ubiquitination	[1]
97	EADEWRFKPIEQLLG	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. 

Sequence Annotation

  

Keyword

 Cell cycle; Cell division; Complete proteome; Cytoplasm; Mitosis; Nucleus; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

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PRINTS