CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041703
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PYD and CARD domain containing 
Protein Synonyms/Alias
 Protein Pycard 
Gene Name
 Pycard 
Gene Synonyms/Alias
 rCG_39389 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
21NLTADEFKKFKMKLLacetylation[1]
22LTADEFKKFKMKLLTacetylation[1]
26EFKKFKMKLLTAPVRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 193 AA 
Protein Sequence
MGRARDAILD ALENLTADEF KKFKMKLLTA PVREGYGRIP RGALLQMDPI DLTDKLVSYY 60
LEGYGLELTM TVLRDMGIQE LAEQLQKIME ESGAVATATS VPAQGTARTE HFVDQHRQAL 120
IARVTEVDGL LDALYGNVLT EGQYQAVRAE TTNQNKMRKL FSFAPAWNLT CKNLFLEALR 180
QTQPYLVTDL EQS 193 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005576; C:extracellular region; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0002218; P:activation of innate immune response; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IMP:RGD.
 GO:0006954; P:inflammatory response; IEA:Compara.
 GO:0032611; P:interleukin-1 beta production; IEA:Compara.
 GO:0044351; P:macropinocytosis; IEA:Compara.
 GO:0002277; P:myeloid dendritic cell activation involved in immune response; IEA:Compara.
 GO:0030838; P:positive regulation of actin filament polymerization; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IEA:Compara.
 GO:0002588; P:positive regulation of antigen processing and presentation of peptide antigen via MHC class II; IEA:Compara.
 GO:0090197; P:positive regulation of chemokine secretion; IEA:Compara.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:RGD.
 GO:0002230; P:positive regulation of defense response to virus by host; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0032729; P:positive regulation of interferon-gamma production; IEA:Compara.
 GO:0032755; P:positive regulation of interleukin-6 production; IEA:Compara.
 GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
 GO:2000406; P:positive regulation of T cell migration; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:InterPro.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0032314; P:regulation of Rac GTPase activity; IEA:Compara. 
Interpro
 IPR001315; CARD.
 IPR004020; DAPIN.
 IPR011029; DEATH-like_dom.
 IPR002398; Pept_C14_p45. 
Pfam
 PF00619; CARD
 PF02758; PYRIN 
SMART
  
PROSITE
 PS50209; CARD
 PS50824; DAPIN 
PRINTS