| Tag | Content |
|---|
| CPLM ID | CPLM-021781 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | THAP domain-containing protein 11 |
Protein Synonyms/Alias | Ronin |
Gene Name | Thap11 |
Gene Synonyms/Alias | MNCb-2032 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 38 | ELRRLWLKNVSRAGV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers. |
Sequence Annotation | ZN_FING 1 80 THAP-type.
MOTIF 234 237 HCFC1-binding motif (HBM) (By |
Keyword | Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 305 AA |
Protein Sequence | MPGFTCCVPG CYNNSHRDKA LHFYTFPKDA ELRRLWLKNV SRAGVSGCFS TFQPTTGHRL 60
CSVHFQGGRK TYTVRVPTIF PLRGVNERKV ARRPAGAAAA RRRQQQQQQQ QQQQQQQQLQ 120
QQQPSPSSST AQTTQLQPNL VSASAAVLLT LQAAVDSNQA PGSVVPVSTT PSGDDVKPID 180
LTVQVEFAAA EGAAAAAAAS ELEAATAGLE AAECTLGPQL VVVGEEGFPD TGSDHSYSLS 240
SGTTEEELLR KLNEQRDILA LMEVKMKEMK GSIRHLRLTE AKLREELREK DRLLAMAVIR 300
KKHGM 305 |
Gene Ontology | GO:0005825; C:half bridge of spindle pole body; IEA:Compara. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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