UniProt Accession

 NHRF2_MOUSE; Q9JHL1; Q3TDR3; Q6P074; Q8BGL9; Q8BW05; Q9DCR6 

Genbank Protein ID

 AB026489; AB026490; AK002557; AK039491; AK075813; AK084801; AK170057; BC065778 

Genbank Nucleotide ID

 BAA97568.1; BAA97569.1; BAB22185.1; BAC30366.1; BAC35980.1; BAC39282.1; BAE41537.1; AAH65778.1 

Protein Name

 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 

Protein Synonyms/Alias

 NHERF-2; NHE3 kinase A regulatory protein E3KARP; Octs2; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1 

Gene Name

 Slc9a3r2 

Gene Synonyms/Alias

 Nherf2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
58	GFNLHSDKSRPGQYI	ubiquitination	[1]
126	PETDEHFKRLRVVPT	ubiquitination	[1]
171	SDLPGSEKDNEDGST	ubiquitination	[1]
180	NEDGSTWKRDPFQES	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (By similarity). 

Sequence Annotation

 DOMAIN 11 91 PDZ 1.
 DOMAIN 151 231 PDZ 2.
 MOD_RES 183 183 Phosphoserine (By similarity).
 MOD_RES 254 254 Phosphoserine (By similarity).
 MOD_RES 272 272 Phosphoserine.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase cascade; IGI:MGI. 

Interpro

 IPR015098; EBP50_C-term.
 IPR017300; NaH_exchngr_reg_CF_NHE-RF.
 IPR001478; PDZ. 

Pfam

 PF09007; EBP50_C-term
 PF00595; PDZ 

SMART

 SM00228; PDZ 

PROSITE

 PS50106; PDZ 

PRINTS