| Tag | Content |
|---|
| CPLM ID | CPLM-014457 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable ATP-dependent RNA helicase DDX46 |
Protein Synonyms/Alias | DEAD box protein 46; Helicase of 117.4 kDa |
Gene Name | Ddx46 |
Gene Synonyms/Alias | Hel117 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 776 | KSSGFSGKGFKFDET | acetylation | [1] | | 848 | PTAGNAEKLEIAKRL | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays an essential role in splicing, either prior to, or during A complex formation (By similarity). |
Sequence Annotation | DOMAIN 403 581 Helicase ATP-binding.
DOMAIN 592 753 Helicase C-terminal.
MOTIF 372 400 Q motif.
MOTIF 529 532 DEAD box.
MOD_RES 263 263 N6-acetyllysine (By similarity).
MOD_RES 294 294 Phosphotyrosine (By similarity).
MOD_RES 295 295 Phosphoserine (By similarity).
MOD_RES 296 296 Phosphoserine (By similarity).
MOD_RES 776 776 N6-acetyllysine (By similarity).
MOD_RES 804 804 Phosphoserine.
MOD_RES 929 929 Phosphoserine (By similarity). |
Keyword | Acetylation; ATP-binding; Coiled coil; Complete proteome; Direct protein sequencing; Helicase; Hydrolase; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1032 AA |
Protein Sequence | MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE RSRSRDKRRS 60
RSRDRKRLRR SRSRERDRSR ERRRSRSRDR RRSRSRSRGR RSRSSSPGSK SKKAENRSRS 120
KEKAEGGDSS KEKKKDKDDK EDEKEKDAGN FDQNKLEEEM RKRKERVEKW REEQRKKAME 180
NIGELKKEIE EMKQGKKWSL EDDDDDEDDP AEAEKEGNEM EDEELDPLDA YMEEVKEEVK 240
KFNMRSVKGG AGNEKKSGPT VTKVVTVVTT KKAVVDADKK KGELMENDQD AMEYSSEEEE 300
VDLQTALTGY QTKQRKLLEP VDHGKIEYEP FRKNFYVEVP ELAKMSQEEV NVFRLEMEGI 360
TVKGKGCPKP IKSWVQCGIS MKILNSLKKH GYEKPTPIQT QAIPAIMSGR DLIGIAKTGS 420
GKTIAFLLPM FRHIMDQRSL EEGEGPIAVI MTPTRELALQ ITKECKKFSK TLGLRVVCVY 480
GGTGISEQIA ELKRGAEIIV CTPGRMIDML AANSGRVTNL RRVTYVVLDE ADRMFDMGFE 540
PQVMRIVDNV RPDRQTVMFS ATFPRAMEAL ARRILSKPIE VQVGGRSVVC SDVEQQVIVI 600
EEEKKFLKLL ELLGHYQESG SVIIFVDKQE HADGLLKDLM RASYPCMSLH GGIDQYDRDS 660
IINDFKNGTC KLLVATSVAA RGLDVKHLIL VVNYSCPNHY EDYVHRAGRT GRAGNKGYAY 720
TFITEDQARY AGDIIKALEL SGTAVPPDLE KLWSDFKDQQ KAEGKIIKKS SGFSGKGFKF 780
DETEQALANE RKKLQKAALG LQDSDDEDAA VDIDEQIESM FNSKKRVKDM AAPGTSSAPA 840
PTAGNAEKLE IAKRLALRIN AQKNLGIESQ VDVMQQATNA ILRGGPLLAP TVSAKTIAEQ 900
LAEKINAKLN YVPLEKQEEE RQEGGQSESF KRYEEELEIN DFPQTARWKV TSKEALQRIS 960
EYSEAAITIR GTYFPPGKEP KEGERKIYLA IESANELAVQ KAKAEITRLI KEELIRLQNS 1020
YQPTNKGRYK VL 1032 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |