CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009963
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin-binding protein H 
Protein Synonyms/Alias
 MyBP-H; H-protein 
Gene Name
 Mybph 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
105EPPEKLGKLGLQGYVubiquitination[1]
146RNLALGDKFFLRVTAubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Binds to myosin; probably involved in interaction with thick myofilaments in the A-band. 
Sequence Annotation
 DOMAIN 77 169 Fibronectin type-III 1.
 DOMAIN 178 266 Ig-like C2-type 1.
 DOMAIN 273 365 Fibronectin type-III 2.
 DOMAIN 388 472 Ig-like C2-type 2.  
Keyword
 Cell adhesion; Complete proteome; Immunoglobulin domain; Muscle protein; Reference proteome; Repeat; Thick filament. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 483 AA 
Protein Sequence
MTGKATSEAS VSTPEETAPE PAKVPTTEPS GEVAASESTG QEQAPEPQKP QAQDPAAPAA 60
SAMPAATKPE PPSEDVPSAP LRLTLEDVSH SSLTVSWEPP EKLGKLGLQG YVLEFCREGA 120
SEWVPVNPRP VMVTQQTVRN LALGDKFFLR VTAVSSAGAG PPAVLDQPVH IQEITEAPKI 180
RVPRHLRQTY IRQVGESVNL QIPFQGKPKP QVSWTHNGHA LDNQRVNVRS GDQDSILFIR 240
SAQRADSGRY ELTVHLEGLE AKASIDILVI EKPGPPSSIK LLDVWGCNAA LEWTPPQDTG 300
NTELLGYTVQ KADKRTGQWF TVLERYHPTT CTISDLIIGN SYSFRVFSEN LCGLSDLATT 360
TKELAHIHKA DITAKPREFI ERDFSEAPSF TQPLADHTST PGYSTQLFCS VRASPKPKII 420
WMKNKMDIQG DPKYRAVSEQ GVCTLEIRKP SPFDSGVYTC KAINVLGEAS VDCRLEVKAS 480
ATH 483 
Gene Ontology
 GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS