CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000613
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Huntingtin-associated protein 1 
Protein Synonyms/Alias
 HAP-1 
Gene Name
 Hap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
273QLETLQQKLRLLEEEubiquitination[1]
346QLQAEITKLQQRCQSubiquitination[1]
369QQMLASEKGIHSESLubiquitination[1]
439ELRTSLRKFITDPAYubiquitination[1]
567NWQDAHSKRQQKQKVubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat. 
Sequence Annotation
 DOMAIN 79 403 HAP1 N-terminal.  
Keyword
 Alternative splicing; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 628 AA 
Protein Sequence
MRPKEQVQSG AGDGTGSGDP AAGTPTTQPA VGPAPEPSAE PKPAPAQGTG SGQKSGSRTK 60
TGSFCRSMII GDSDAPWTRY VFQGPYGPRA TGLGTGKAEG IWKTPAAYIG RRPGVSGPER 120
AAFIRELQEA LCPNPPPTKK ITEDDVKVML YLLEEKERDL NTAARIGQSL VKQNSVLMEE 180
NNKLETMLGS AREEILHLRK QVNLRDDLLQ LYSDSDDDDD EEDEEDEEEG EEEEREGQRD 240
QDQQHDHPYG APKPHPKAET AHRCPQLETL QQKLRLLEEE NDHLREEASH LDNLEDEEQM 300
LILECVEQFS EASQQMAELS EVLVLRLEGY ERQQKEITQL QAEITKLQQR CQSYGAQTEK 360
LQQMLASEKG IHSESLRAGS YMQDYGSRPR DRQEDGKSHR QRSSMPAGSV THYGYSVPLD 420
ALPSFPETLA EELRTSLRKF ITDPAYFMER RDTHCREGRK KEQRAMPPPP AQDLKPPEDF 480
EAPEELVPEE ELGAIEEVGT AEDGQAEENE QASEETEAWE EVEPEVDETT RMNVVVSALE 540
ASGLGPSHLD MKYVLQQLSN WQDAHSKRQQ KQKVVPKDSP TPQQQTNMGG GILEQQPRVP 600
TQDSQRLEED RATHSPSARE EEGPSGAT 628 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0047496; P:vesicle transport along microtubule; IMP:MGI. 
Interpro
 IPR006933; HAP1_N. 
Pfam
 PF04849; HAP1_N 
SMART
  
PROSITE
  
PRINTS