CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010191
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low specificity L-threonine aldolase 
Protein Synonyms/Alias
 Low specificity L-TA 
Gene Name
 ltaE 
Gene Synonyms/Alias
 ybjU; b0870; JW0854 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
119PLDKVAMKIKPDDIHacetylation[1]
142LENTHNGKVLPREYLacetylation[1]
150VLPREYLKEAWEFTRacetylation[1]
215VGNRDYIKRAIRWRKacetylation[1]
243AAGIYALKNNVARLQacetylation[1]
295AALGEYMKARNVLINacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates. 
Sequence Annotation
 MOD_RES 197 197 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Complete proteome; Direct protein sequencing; Lyase; Pyridoxal phosphate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 333 AA 
Protein Sequence
MIDLRSDTVT RPSRAMLEAM MAAPVGDDVY GDDPTVNALQ DYAAELSGKE AAIFLPTGTQ 60
ANLVALLSHC ERGEEYIVGQ AAHNYLFEAG GAAVLGSIQP QPIDAAADGT LPLDKVAMKI 120
KPDDIHFART KLLSLENTHN GKVLPREYLK EAWEFTRERN LALHVDGARI FNAVVAYGCE 180
LKEITQYCDS FTICLSKGLG TPVGSLLVGN RDYIKRAIRW RKMTGGGMRQ SGILAAAGIY 240
ALKNNVARLQ EDHDNAAWMA EQLREAGADV MRQDTNMLFV RVGEENAAAL GEYMKARNVL 300
INASPIVRLV THLDVSREQL AEVAAHWRAF LAR 333 
Gene Ontology
 GO:0008732; F:L-allo-threonine aldolase activity; IDA:EcoCyc.
 GO:0050179; F:phenylserine aldolase activity; IDA:EcoCyc.
 GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc.
 GO:0006545; P:glycine biosynthetic process; IGI:EcoCyc. 
Interpro
 IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR023603; Threonine_aldolase. 
Pfam
 PF01212; Beta_elim_lyase 
SMART
  
PROSITE
  
PRINTS