| Tag | Content |
|---|
| CPLM ID | CPLM-011916 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Potassium voltage-gated channel subfamily H member 2 |
Protein Synonyms/Alias | Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1 |
Gene Name | KCNH2 |
Gene Synonyms/Alias | ERG; ERG1; HERG |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | ADVLPEYKLQAPRIH | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1. |
Sequence Annotation | DOMAIN 41 70 PAS.
DOMAIN 92 144 PAC.
NP_BIND 742 842 cNMP.
MOTIF 624 629 Selectivity filter (By similarity).
MOD_RES 320 320 Phosphoserine.
CARBOHYD 598 598 N-linked (GlcNAc...). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Deafness; Disease mutation; Glycoprotein; Ion channel; Ion transport; Long QT syndrome; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Short QT syndrome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1159 AA |
Protein Sequence | MAAPAGKASR TGALRPRAQK GRVRRAVRIS SLVAQEVLSL GADVLPEYKL QAPRIHRWTI 60
LHYSPFKAVW DWLILLLVIY TAVFTPYSAA FLLKETEEGP PATECGYACQ PLAVVDLIVD 120
IMFIVDILIN FRTTYVNANE EVVSHPGRIA VHYFKGWFLI DMVAAIPFDL LIFGSGSEEL 180
IGLLKTARLL RLVRVARKLD RYSEYGAAVL FLLMCTFALI AHWLACIWYA IGNMEQPHMD 240
SRIGWLHNLG DQIGKPYNSS GLGGPSIKDK YVTALYFTFS SLTSVGFGNV SPNTNSEKIF 300
SICVMLIGSL MYASIFGNVS AIIQRLYSGT ARYHTQMLRV REFIRFHQIP NPLRQRLEEY 360
FQHAWSYTNG IDMNAVLKGF PECLQADICL HLNRSLLQHC KPFRGATKGC LRALAMKFKT 420
THAPPGDTLV HAGDLLTALY FISRGSIEIL RGDVVVAILG KNDIFGEPLN LYARPGKSNG 480
DVRALTYCDL HKIHRDDLLE VLDMYPEFSD HFWSSLEITF NLRDTNMIPG SPGSTELEGG 540
FSRQRKRKLS FRRRTDKDTE QPGEVSALGP GRAGAGPSSR GRPGGPWGES PSSGPSSPES 600
SEDEGPGRSS SPLRLVPFSS PRPPGEPPGG EPLMEDCEKS SDTCNPLSGA FSGVSNIFSF 660
WGDSRGRQYQ ELPRCPAPTP SLLNIPLSSP GRRPRGDVES RLDALQRQLN RLETRLSADM 720
ATVLQLLQRQ MTLVPPAYSA VTTPGPGPTS TSPLLPVSPL PTLTLDSLSQ VSQFMACEEL 780
PPGAPELPQE GPTRRLSLPG QLGALTSQPL HRHGSDPGS 819 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005635; C:nuclear envelope; IEA:Compara. GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc. GO:0005251; F:delayed rectifier potassium channel activity; TAS:ProtInc. GO:0005242; F:inward rectifier potassium channel activity; IEA:Compara. GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro. GO:0008015; P:blood circulation; NAS:ProtInc. GO:0006936; P:muscle contraction; TAS:ProtInc. GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:MGI. GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Compara. GO:0023014; P:signal transduction by phosphorylation; IEA:GOC. GO:0007268; P:synaptic transmission; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |