| Tag | Content |
|---|
| CPLM ID | CPLM-015347 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acyl-coenzyme A thioesterase 5 |
Protein Synonyms/Alias | Acyl-CoA thioesterase 5; Peroxisomal acyl-coenzyme A thioester hydrolase Ic; Peroxisomal acyl-CoA thioesterase Ic |
Gene Name | Acot5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 42 | RTALRDEKGALFRAH | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels. Mainly active on medium-chain acyl- CoAs. May have a function in termination of beta-oxidation of fatty acids. |
Sequence Annotation | MOTIF 419 421 Microbody targeting signal (Potential).
ACT_SITE 232 232 Charge relay system (By similarity).
ACT_SITE 326 326 Charge relay system (By similarity).
ACT_SITE 360 360 Charge relay system (By similarity).
MOD_RES 56 56 Phosphoserine. |
Keyword | Complete proteome; Hydrolase; Peroxisome; Phosphoprotein; Reference proteome; Serine esterase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 421 AA |
Protein Sequence | MVPTVSLEPT GHSCWDEPLS IAVRGLAPEQ PVTLRTALRD EKGALFRAHA RYRADSHGEL 60
DLARTPALGG SFSGLEPMGL LWAMEPDRPF WRLIKRDVQT PFVVELEVLD GHEPDGGRLL 120
ARAVHERHFM APGVRRVPVR EGRVRATLFL PPGTGPFPGI IDLFGVGGGL LEYRASLLAG 180
KGFAVMALAY YKYDDLPKVI DILHLEYFEE AVTYLLSHPQ VKGPGVGLLG ISKGAELSLS 240
MASFLKGITA AVVINGATVN VISTLYYKEE SLPGLGMHLE RIKVTKDGFK DIIDILNVPL 300
EAPDQKSLIP LERSDTAFLF LVGQDDHNWK SEFYAREASK RLQAHGKEKP QIVCYPKTGH 360
HIEPPYIPWS IAAPHSYFDK PILLGGEPRA HAMAQVDAWQ RLQTFFHKHL SGDKRPSPAK 420
L 421 |
Gene Ontology | GO:0005829; C:cytosol; IDA:MGI. GO:0005777; C:peroxisome; TAS:HGNC. GO:0047617; F:acyl-CoA hydrolase activity; IDA:HGNC. GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:EC. GO:0006637; P:acyl-CoA metabolic process; IDA:HGNC. GO:0001676; P:long-chain fatty acid metabolic process; IDA:HGNC. GO:0032788; P:saturated monocarboxylic acid metabolic process; IDA:HGNC. GO:0032789; P:unsaturated monocarboxylic acid metabolic process; IDA:HGNC. GO:0000038; P:very long-chain fatty acid metabolic process; IDA:HGNC. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |