| Tag | Content |
|---|
| CPLM ID | CPLM-023489 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PH domain leucine-rich repeat protein phosphatase 1 |
Protein Synonyms/Alias | Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein |
Gene Name | Phlpp1 |
Gene Synonyms/Alias | Phlpp; Plekhe1; Scop |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 214 | RLLQLGHKGGGVVKV | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor (By similarity). May act as a negative regulator of K-Ras signaling in membrane rafts. |
Sequence Annotation | DOMAIN 499 599 PH.
REPEAT 601 622 LRR 1.
REPEAT 624 645 LRR 2.
REPEAT 655 676 LRR 3.
REPEAT 678 699 LRR 4.
REPEAT 701 722 LRR 5.
REPEAT 724 746 LRR 6.
REPEAT 836 857 LRR 7.
REPEAT 858 879 LRR 8.
REPEAT 881 902 LRR 9.
REPEAT 904 925 LRR 10.
REPEAT 926 947 LRR 11.
REPEAT 950 971 LRR 12.
REPEAT 976 996 LRR 13.
REPEAT 1000 1021 LRR 14.
REPEAT 1024 1045 LRR 15.
REPEAT 1047 1068 LRR 16.
REPEAT 1069 1090 LRR 17.
REPEAT 1092 1113 LRR 18.
DOMAIN 1128 1383 PP2C-like.
MOTIF 1694 1696 PDZ-binding.
METAL 1173 1173 Manganese 1 (By similarity).
METAL 1173 1173 Manganese 2 (By similarity).
METAL 1174 1174 Manganese 1; via carbonyl oxygen (By
METAL 1337 1337 Manganese 2 (By similarity).
METAL 1376 1376 Manganese 2 (By similarity). |
Keyword | Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Leucine-rich repeat; Manganese; Membrane; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Repeat; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1696 AA |
Protein Sequence | MEPAAAAPAQ RLADPTGEDR APAAAAAAEG GRSPDSVLSA AAPSGGNGGA AREEAPCEAP 60
PGPLPGRAGG TGRRRRRGVP QPAAGGAAPV TAAGGGANSL LLRRGRLKRN LSAAASSSSS 120
PSSASSAAGG LPASCSASAS LCTRSLDRKT LLQKHRQLLQ LQPSDRDWVR HQLQRGCVHV 180
FDRHMASSYL RPVLCTLDTT AAEVAARLLQ LGHKGGGVVK VLGHGPPPAA APAASDQTPA 240
TELGRDVEPP PSSSTVGAVR GPARAPPADL PLPGGAWTRC APRVNPAPSD SSPGELFAGG 300
PCSPSRAPRP ASDTESFSLS PSAESVSDRL DPYSSGGGSS SSSEELEADP ATVLTGPSGP 360
PHHPVRSSQP RPPSPKTSAL LQPKAPTGVD GTGLVVGEGP GDDKAVAAAA PGVPLWTPGR 420
IRETVQKTSS PPSLYVQLHG ETTRRLEADE KPLQIQNDYL FQLGFGELWR VQEEGMDSEI 480
GCLIRFYAGK PHSTGSSERI QLSGMYNVRK GKMQLPVNRW TRRQVILCGT CLIVSSVKDS 540
SSGKMHVLPL IGGKVEEVKK HQHCLAFSSS GPQSQTYYIC FDTFTEYLRW LRQVSKVASQ 600
RISSVDLSCC SLEHLPANLF YSQDLTHLNL KQNFLRQNPS LPAARGLGEL QRFTKLKSLN 660
LSNNHLGAFP SAVCSIPTLA ELNVSCNALQ EVPAAVGAMQ NLQTFLLDGN FLQSLPAELE 720
NMHQLSYLGL SFNEFTDIPE VLEKLTAVDK LCMAGNCMET LRLQALRRMP HIKHVDLRLN 780
ILRKLITDEV DFLQHVTQLD LRDNKLGDLD AMIFNNIEVL HCERNQLVTL NICGYFLKAL 840
YASSNELVQL DVYPVPNYLS YMDVSRNCLE SVPEWVCESR KLEVLDIGHN QICELPARLF 900
CNSSLRKLLA GHNRLARLPE RLERTSVEVL DVQHNQIIEL PPNLLMKADS LRFLNASANK 960
LETLPPATLS EETSSILQEL YLTNNSLTDK CVPLLTGHPR LKILHMAYNR LQSFPASKMA 1020
KLEELEEIDI SGNKLKAIPT TIMNCRRMHT VIAHSNCIEV FPEVMQLPEV KCVDLSCNEL 1080
SEITLPENLP PKLQELDLTG NPRLALDHKS LELLNNIRCF KIDQPSAGDA SGAPAVWSHG 1140
YTEASGVKNK LCVAALSVNN FRDNREALYG VFDGDRNVEV PYLLQCTMSD ILAEELQKTK 1200
NEEEYMVNTF IVMQRKLGTA GQKLGGAAVL CHIRHDPVDL GGSFTLTSAN VGKCQTVLCR 1260
NGKPLSLSRS YTMSCEEERK RIKQHKAIIT EDGKVNGVTE STRILGYTFL HPSVVPRPHV 1320
QSVLLTPQDE FFILGSKGLW DSLSIEEAVE AVRNVPDALA AAKKLCTLAQ SYGCHDSISA 1380
VVVQLSVTED SFCCCELSVG GSMPPPSPGI FPPSVSMVIK DRPSDGLGVP SSSSGMASEI 1440
SSELSTSEMS SEVGSTASDE PPSGALSESS PAYPSEQRCM LHPVCLSNSF QRQLSSATFS 1500
SAFSDNGLDS DDEEPIEGVF SNGSRVEVEV DIHCSRAKEK ERQQHLLQVP AEASDEGIVI 1560
SANEDESGLS KKTDISAVGT IGRRRANGSV PPQERSHNVI EVATDAPLRK PGGYFAAPAQ 1620
PDPDDQFIIP PELEEEVKEI MKHHQEQQQQ QQQQQQQQQQ QPPPPPQPPQ AQAQAQAQAQ 1680
RPFQMDHLPD CYDTPL 1696 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0016020; C:membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0004722; F:protein serine/threonine phosphatase activity; IDA:RGD. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007623; P:circadian rhythm; IEP:RGD. GO:0006470; P:protein dephosphorylation; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |