CPLM-022140

Genbank Nucleotide ID

Ethylmalonyl-CoA decarboxylase

Protein Synonyms/Alias

Enoyl-CoA hydratase domain-containing protein 1; Methylmalonyl-CoA decarboxylase; MMCD

Homo sapiens (Human)

Position	Peptide	Type	References
9	ALKQEMAKSLLKTAS	ubiquitination	[1]
45	FYEEEVKKTLQQFPG	ubiquitination	[2, 3, 4, 5]
59	GGSIDLQKEDNGIGI	ubiquitination	[3]
100	LENWTEGKGLIVRGA	ubiquitination	[1, 3]
108	GLIVRGAKNTFSSGS	ubiquitination	[1, 3]
179	RLMTPESKIRFVHKE	ubiquitination	[1, 3]
210	IGSRQALKVLSGALK	ubiquitination	[1, 2, 5]
221	GALKLDSKNALNIGM	ubiquitination	[1, 3]
250	EEAQEWLKQFIQGPP	ubiquitination	[6]
301	ANLEAIAKKGKFNK*	ubiquitination	[3]
302	NLEAIAKKGKFNK**	ubiquitination	[1]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activityx at lower level.

Alternative splicing; Complete proteome; Cytoplasm; Lyase; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0016831; F:carboxy-lyase activity; ISS:UniProtKB.
GO:0004492; F:methylmalonyl-CoA decarboxylase activity; IEA:EC.

IPR001753; Crotonase_core_superfam.
IPR018376; Enoyl-CoA_hyd/isom_CS.

PS00166; ENOYL_COA_HYDRATASE