CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019849
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein amnionless 
Protein Synonyms/Alias
  
Gene Name
 Amn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
432ELPDSAQKVDILDIDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Necessary for efficient absorption of vitamin B12 (By similarity). May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm. 
Sequence Annotation
 DOMAIN 203 254 VWFC.
 CARBOHYD 27 27 N-linked (GlcNAc...) (Potential).
 CARBOHYD 355 355 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Developmental protein; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 458 AA 
Protein Sequence
MGALGRVLLW LQLCAMTRAA YKLWVPNTSF DTASNWNQNR TPCAGDAVQF PADKMVSVLV 60
RDSHAISDML LPLDGELVLA SGAALSAAGG DSDPACNPGA PLLFRNPDRF SWLDPHLWSS 120
GTQAPGLFSV DAERVPCSYD DVLFPRDGSF RVALGPGPNP VHVRSVSAVG QTFSRDEDLT 180
AFLASREGRL RFHGSGALRV GSQACTDASG CVCGNAEMLP WICASLLQPL GGRCPQAACQ 240
DPLLPQGQCC DLCGAIVSLT HDPTFDLERY RARLLDLFLK QPQYQGLQVA VSKVLRDAHT 300
EIQVVLVETE HATGAAGQLG HALLQDAVAQ GSVLGIVSAT LRQSGKPMTA DSELNQSSSG 360
AGLAGGVAAL VLLALLGTVL LLLHRSGRLR WRRHEDAEPV SAGLPLGFRN PIFDAIVFKQ 420
QPSVELPDSA QKVDILDIDT KFGCFVNPLF AGEAEAEA 458 
Gene Ontology
 GO:0045177; C:apical part of cell; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007588; P:excretion; IMP:MGI.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0008104; P:protein localization; IMP:MGI. 
Interpro
 IPR026112; AMN. 
Pfam
  
SMART
  
PROSITE
 PS01208; VWFC_1
 PS50184; VWFC_2 
PRINTS