CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007410
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 La protein homolog 
Protein Synonyms/Alias
 La autoantigen homolog; La ribonucleoprotein 
Gene Name
 La 
Gene Synonyms/Alias
 CG10922 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
49EAAGGFTKQERAIIRacetylation[1]
233KWQVDYLKEKQEEYAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 May be involved in transcription termination by RNA polymerase III. Binds RNA and DNA. Binds to precursors of RNA polymerase III transcripts. May play a specialized role during fly development. 
Sequence Annotation
 DOMAIN 44 137 HTH La-type RNA-binding.
 DOMAIN 149 234 RRM.
 MOD_RES 7 7 Phosphothreonine.
 MOD_RES 9 9 Phosphoserine.  
Keyword
 Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 390 AA 
Protein Sequence
MAEVAETPSV EAQEEVAQPA EAQVLEAKNG DAKKDPAPAA EEAAGGFTKQ ERAIIRQVEY 60
YFGDANLNRD KFLREQIGKN EDGWVPLSVL VTFKRLASLS TDLSEIVAAL NKSEEGLVEI 120
SEDKLSLRRH PERPIPEHNE ERRKEIQERT AYAKGFPLDS QISELLDFAA NYDKVVNLTM 180
RKHYDKPTKS YKFKGSIFLT FETKDQAKAF LEQEKIVYKE RELLRKWQVD YLKEKQEEYA 240
QKNEKRKNKK EAKPEPAFEL PKNAIVVFEG APETSSREEI REAFEKIKDF EVAYIEFAKG 300
ETKGSVRLTE ADAAEKYIAK VEEGKLKFKD EVSLSLRKAT EEEEKEFIDK AIEFMKKRRD 360
FTRNKGKRFN RKRHGGNDHK HGGGKKARGD 390 
Gene Ontology
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0030529; C:ribonucleoprotein complex; IEA:InterPro.
 GO:0008098; F:5S rRNA primary transcript binding; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003729; F:mRNA binding; ISS:FlyBase.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR002344; Lupus_La.
 IPR006630; Lupus_La_RNA-bd.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR014886; RRM_3.
 IPR000504; RRM_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF05383; La
 PF08777; RRM_3 
SMART
 SM00715; LA
 SM00360; RRM 
PROSITE
 PS50961; HTH_LA
 PS50102; RRM 
PRINTS
 PR00302; LUPUSLA.