| Tag | Content |
|---|
| CPLM ID | CPLM-012425 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | E3 ubiquitin-protein ligase SHPRH |
Protein Synonyms/Alias | SNF2, histone-linker, PHD and RING finger domain-containing helicase |
Gene Name | SHPRH |
Gene Synonyms/Alias | KIAA2023 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1260 | LFTEYESKLFSNTVK | ubiquitination | [1] | | 1566 | FAQISRVKTFQENLS | ubiquitination | [1] | | 1576 | QENLSAFKRDPQINI | ubiquitination | [1] |
|
Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. |
Sequence Annotation | DOMAIN 307 389 Helicase ATP-binding; first part.
DOMAIN 438 512 H15.
DOMAIN 710 868 Helicase ATP-binding; second part.
DOMAIN 1514 1672 Helicase C-terminal.
NP_BIND 373 380 ATP (By similarity).
ZN_FING 658 709 PHD-type.
ZN_FING 1432 1479 RING-type.
MOTIF 819 822 DEAQ box.
MOD_RES 266 266 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; DNA damage; DNA repair; Helicase; Hydrolase; Ligase; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1683 AA |
Protein Sequence | MSSRRKRAPP VRVDEEKRQQ LHWNMHEDRR NEPIIISDDD EQPCPGSDTS SAHYIILSDS 60
LKEEVAHRDK KRCSKVVSFS KPIEKEETVG IFSPLSVKLN IVISPYHFDN SWKAFLGELT 120
LQLLPAQSLI ENFSERSITL MSSESSNQFL IYVHSKGEDV EKQKKEPMSI CDKGILVESS 180
FSGEMLEDLG WLQKKRRIKL YQKPEGNHII KVGIYLLEAG LAKLDFLSDA NSRMKKFNQL 240
MKKVMEKLHN SIIPDVLEED EDDPESEPEG QDIDELYHFV KQTHQQETQS IQVDVQHPAL 300
IPVLRPYQRE AVNWMLQQEC FRSSPATESA LHFLWREIVT SEGLKLYYNP YTGCIIREYP 360
NSGPQLLGGI LADEMGLGKT VEVLALILTH TRQDVKQDAL TLPEGKVVNY FIPSHYFGGK 420
LKKTEIQNIE FEPKEKVQCP PTRVMILTAV KEMNGKKGVS ILSIYKYVSS IYRYDVQRNR 480
SLLKRMLKCL IFEGLVKQIK GHGFSGTFTL GKNYKEEDIC DKTKKQAVGS PRKIQKETRK 540
SGNKDTDSEY LPSDTSDDDD DPYYYYYKSR RNRSKLRKKL VPSTKKGKSQ PFINPDSQGH 600
CPATSDSGIT DVAMSKSTCI SEFNQEHETE DCAESLNHAD SDVPPSNTMS PFNTSDYRFE 660
CICGELDQID RKPRVQCLKC HLWQHAKCVN YDEKNLKIKP FYCPHCLVAM EPVSTRATLI 720
ISPSSICHQW VDEINRHVRS SSLRVLVYQG VKKDGFLQPH FLAEQDIVII TYDVLRSELN 780
YVDIPHSNSE DGRRLRNQKR YMAIPSPLVA VEWWRICLDE AQMVECPTVK AAEMAQRLSG 840
INRWCISGTP VQRGLEDLFG LVVFLGIEPY CVKHWWVRLL YRPYCKKNPQ HLYSFIAKIL 900
WRSAKKDVID QIQIPPQTEE IHWLHFSPVE RHFYHRQHEV CCQDVVVKLR KISDWALKLS 960
SLDRRTVTSI LYPLLRLRQA CCHPQAVRGE FLPLQKSFEQ STFSFSTMTM EELLTSLQKK 1020
CGTECEEAHR QLVCALNGLA GIHIIKGEYA LAAELYREVL RSSEEHKGKL KTDSLQRLHA 1080
THNLMELLIA RHPGIPPTLR DGRLEEEAKQ LREHYMSKCN TEVAEAQQAL YPVQQTIHEL 1140
QRKIHSNSPW WLNVIHRAIE FTIDEELVQR VRNEITSNYK QQTGKLSMSE KGLQFLLTTQ 1200
MEELNKCQKL VREAVKNLEG PPSRNVIESA TVCHLRPARL PLNCCVFCKA DELFTEYESK 1260
LFSNTVKGQT AIFEEMIEDE EGLVDDRAPT TTRGLWAISE TERSMKAILS FAKSHRFDVE 1320
FVDEGSTSMD LFEAWKKEYK LLHEYWMALR NRVSAVDELA MATERLRVRD PREPKPNPPV 1380
LHIIEPHEVE QNRIKLLNDK AVATSQLQKK LGQLLYLTNL EKSQDKTSGG VNPEPCPICA 1440
RQLGKQWAVL TCGHCFCNEC ISIIIEQYSV GSHRSSIKCA ICRQTTSHKE ISYVFTSEKA 1500
NQEEDIPVKG SHSTKVEAVV RTLMKIQLRD PGAKALVFST WQDVLDIISK ALTDNNMEFA 1560
QISRVKTFQE NLSAFKRDPQ INILLLPLHT GSNGLTIIEA THVLLVEPIL NPAHELQAIG 1620
RVHRIGQTKP TIVHRFLIKA TIEERMQAML KTAERSIYI 1659 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |