UniProt Accession

 ATP5E_RAT; P29418 

Genbank Protein ID

 AF010323; BC058133 

Genbank Nucleotide ID

 AAB64162.1; AAH58133.1 

Protein Name

 ATP synthase subunit epsilon, mitochondrial 

Protein Synonyms/Alias

 ATPase subunit epsilon 

Gene Name

 Atp5e 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
37	EFKANAEKTSGTSIK	acetylation	[1]
44	KTSGTSIKTVKIKKE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. 

Sequence Annotation

 MOD_RES 21 21 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP synthesis; CF(1); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 51 AA 

Protein Sequence

Gene Ontology

 GO:0000275; C:mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); IDA:RGD.
 GO:0016887; F:ATPase activity; IMP:RGD.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0006172; P:ADP biosynthetic process; IDA:RGD.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR006721; ATPase_F1-cplx_esu_mt. 

Pfam

 PF04627; ATP-synt_Eps 

SMART

  

PROSITE

  

PRINTS