CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013636
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prolyl endopeptidase-like 
Protein Synonyms/Alias
 Prolylendopeptidase-like 
Gene Name
 Prepl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
438GHEDPITKTSRVLRIubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue (By similarity). 
Sequence Annotation
 ACT_SITE 558 558 Charge relay system (By similarity).
 ACT_SITE 644 644 Charge relay system (By similarity).
 ACT_SITE 689 689 Charge relay system (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Protease; Reference proteome; Serine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 726 AA 
Protein Sequence
MQQTTKLFLG ALKYSIPHLG KCMPKQNYCN VADPYYNRLR LKNYRLTKCL QNKPKISELA 60
RNIPSRSFSV KDKLEKPESL QKRGINICMD AFEKVRTRLE TQPQEEYEIV NAEIKHGGFV 120
YYQEGCCLVR SKDEEADSDN YEVLFNLEEL KLEQPFIDCI RVAPDEKYVA AKIRAEDSET 180
STCIVVKLSD QPAMEASFPN VSSFEWVKDE EDEDVLFYTF QRNLRCHDVY RATFGDNKRN 240
ERFYTEKDPS YFVFLYLTKD SRFLTLNIMN KTTSEVWLID GLSPWDPPML IQKRIHGMLY 300
YVEHRDDELY ILTNVGEPTE FKLMRTAADA PAIMNWDLFF TMKRNTKVVD LDMFKDHCVL 360
FLKHSNLLYV NVIGLADDSV RSLKLPPWAC GFIMDTNSDP KNCPFQLCSP IRPPKYYTYK 420
FAEGKLFEET GHEDPITKTS RVLRIEAKSK DGKLVPMTVF HKTDSEDLQR KPLLVHVYGA 480
YGMDLKMNFR PERRVLVDDG WILAYCHVRG GGELGLQWHA DGRLTKKLNG LADLEACIKT 540
LHSQGFSQPS LTTLSAFSAG GVLVGALCNS KPELLRAVTL EAPFLDVLNT MMDTTLPLTL 600
EELEEWGNPS SDEKHKNYIK RYCPCQNMKP QHYPSVHITA YENDERVPLK GIVNYTEKLK 660
EAVAEHSKGA GEGYQPPNIV LDIQPGGNHV IEDSHKKITT QMKFLYDELG LDSTDAFEAL 720
KKYLKV 726 
Gene Ontology
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001375; Peptidase_S9.
 IPR002470; Peptidase_S9A.
 IPR004106; Peptidase_S9A_B_C_N. 
Pfam
 PF00326; Peptidase_S9
 PF02897; Peptidase_S9_N 
SMART
  
PROSITE
 PS00708; PRO_ENDOPEP_SER 
PRINTS
 PR00862; PROLIGOPTASE.