UniProt Accession

 EMC4_HUMAN; Q5J8M3; A8K3A9; B4DJQ4; Q96KX9; Q9BUI5; Q9P0T9 

Genbank Protein ID

 AY336092; AF151018; AK075227; AK290524; AK296184; AC079203; CH471125; BC002583 

Genbank Nucleotide ID

 AAR24622.1; AAF36104.1; BAC11486.1; BAF83213.1; BAG58916.1; EAW92292.1; AAH02583.1 

Protein Name

 ER membrane protein complex subunit 4 

Protein Synonyms/Alias

 Cell proliferation-inducing gene 17 protein; Transmembrane protein 85 

Gene Name

 EMC4 

Gene Synonyms/Alias

 TMEM85; HSPC184; PIG17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	ANRGRRFKWAIELSG	ubiquitination	[1]
50	YPVGYLDKQVPDTSV	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 May mediate anti-apoptotic activity. 

Sequence Annotation

  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0072546; C:ER membrane protein complex; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. 

Interpro

 IPR009445; DUF1077_TMEM85. 

Pfam

 PF06417; DUF1077 

SMART

  

PROSITE

  

PRINTS