Tag | Content |
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CPLM ID | CPLM-016750 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-like modifier-activating enzyme 6 |
Protein Synonyms/Alias | Ubiquitin-activating enzyme 6; Ubiquitin-activating enzyme E1-like protein 2; E1-L2 |
Gene Name | Uba6 |
Gene Synonyms/Alias | Ube1l2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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503 | TDPDLIEKSNLNRQF | ubiquitination | [1] | 544 | KIDAHLNKVCPATES | ubiquitination | [1] | 652 | FESSFSHKPSLFNKF | ubiquitination | [1] | 739 | SLFWQSPKRPPSPIK | ubiquitination | [1] | 836 | EEALSSNKATKSDLQ | ubiquitination | [1] | 839 | LSSNKATKSDLQMTV | ubiquitination | [1] | 882 | IEPADRFKTKRIAGK | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34 (By similarity). Essential for embryonic development. Required for UBD/FAT10 conjugation. |
Sequence Annotation | NP_BIND 470 500 ATP (By similarity). ACT_SITE 625 625 Glycyl thioester intermediate. MOD_RES 1 1 N-acetylmethionine (By similarity). MOD_RES 544 544 N6-acetyllysine (By similarity). |
Keyword | Acetylation; ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1053 AA |
Protein Sequence | MERSEPLAVL SCEEASCSSW GACGASKNLP TMTTESLEID DGLYSRQRYV LGDTAMQKMA 60 KSCVFLSGMG GLGVEIAKNL VLAGIKALTI HDTKKCQAWD LGTNFFLCED DVVNERNRAE 120 AVLHRIAELN PYVQVSSSSA PLDETTDLSF LEKYQCVVLT EIKLTLQKKI NNFCHSHCPP 180 IKFISADVHG IWSRLFCDFG DEFEVSDTTG EEPKEIFISN ITQANPGIVT CLESHPHKLE 240 TGQFLTFREI HGMTGLNGSV QQITVISPFS FSIGDTTKLD PYLHGGIAVQ VKTPKTFCFE 300 PLESQIKHPR CLIADFSKPE APLEIHLAML ALDQFQENYN RKPNIRCQQD SDELLKLTVS 360 INETLEEKPE VNADIVHWLS WTAQGFLPPL AAAVGGVASQ EVLKAVTGKF SPLCQWLYLE 420 AADTVESLGN PGHEEFLPRG DRYDAIRACI GNTLCQKLQN LNIFLVGCGA IGCEMLKNFA 480 LLGVGTGREK GMVTVTDPDL IEKSNLNRQF LFRPHHIQKP KSYTAAEATL KINPQLKIDA 540 HLNKVCPATE SIYSDEFYTK QDIIITALDN VEARRYVDSR CLANLRPLLD SGTMGTKGHT 600 EIIVPQLTES YNSHRDPPEE EIPFCTLKSF PAAIEHTIQW ARDKFESSFS HKPSLFNKFW 660 QAYPSAEDVL QKIQNGQSLE GCFQVIKLLS RRPRIWSQCV ELARLKFEKY FNHKALQLLH 720 CFPLETRLKD GSLFWQSPKR PPSPIKFDLN EPLHLSFLQS AAKLYATVYC IPFSEKDLSV 780 NSLMDILSEV KIEEFKPSNK VVQTDETARK PDHVPVSSED ERNAVFQLEE ALSSNKATKS 840 DLQMTVLSFE KDDDRNGHID FITAASNLRA KMYSIEPADR FKTKRIAGKI IPAIATSTAA 900 VSGLVALEMI KVAGGYPFDA YKNCFLNLAI PIIVFTETSE VRKTEIRNGI SFTIWDRWTV 960 HGKEDFTLSD FINAVKENYG IEPTMVVQGV KMLYVPVMPG HAKRLKLTMH KLVKPSTEKK 1020 YVDLTVSFAP DADGDEDLPG PPVRYYFSHD TNE 1053 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:Compara. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0019780; F:FAT10 activating enzyme activity; IMP:UniProtKB. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; IMP:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:UniProtKB. |
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