UniProt Accession

 SCS2_YEAST; P40075; D3DM26 

Genbank Protein ID

 D44493; U18916; AY693125; BK006939 

Genbank Nucleotide ID

 BAA07936.1; AAC03218.1; AAT93144.1; DAA07780.1 

Protein Name

 Vesicle-associated membrane protein-associated protein SCS2 

Protein Synonyms/Alias

 VAMP-associated protein SCS2; Choline sensitivity suppressor protein 2; VAP homolog 1 

Gene Name

 SCS2 

Gene Synonyms/Alias

 YER120W 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
124	ISKKIKVKYLISPDV	acetylation	[1]
143	NQNIQENKETVEPVV	ubiquitination	[2]
156	VVQDSEPKEVPAVVN	ubiquitination	[2]
165	VPAVVNEKEVPAEPE	acetylation	[1]
165	VPAVVNEKEVPAEPE	ubiquitination	[2]
180	TQPPVQVKKEEVPPV	sumoylation	[3]
181	QPPVQVKKEEVPPVV	ubiquitination	[2]
190	EVPPVVQKTVPHENE	acetylation	[1]
198	TVPHENEKQTSNSTP	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway.
 Felberbaum R, Wilson NR, Cheng D, Peng J, Hochstrasser M.
 Mol Cell Biol. 2012 Jan;32(1):64-75. [PMID: 22025676] 

Functional Description

 Targets proteins containing a FFAT motif to endoplasmic reticulum membranes. Regulates phospholipid biosynthesis by modulating the subcellular localization of the transcriptional repressor OPI1. 

Sequence Annotation

 DOMAIN 3 126 MSP.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 106 106 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:SGD.
 GO:0031965; C:nuclear membrane; IDA:SGD.
 GO:0033149; F:FFAT motif binding; IMP:SGD.
 GO:0035091; F:phosphatidylinositol binding; IDA:SGD.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006348; P:chromatin silencing at telomere; IMP:SGD.
 GO:0048309; P:endoplasmic reticulum inheritance; IMP:SGD.
 GO:0090158; P:endoplasmic reticulum membrane organization; IGI:SGD.
 GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:SGD.
 GO:0008654; P:phospholipid biosynthetic process; IMP:SGD.
 GO:0032377; P:regulation of intracellular lipid transport; IMP:SGD.
 GO:0060304; P:regulation of phosphatidylinositol dephosphorylation; IGI:SGD. 

Interpro

 IPR000535; Major_sperm.
 IPR008962; PapD-like.
 IPR016763; Vesicle-associated_membrane. 

Pfam

 PF00635; Motile_Sperm 

SMART

  

PROSITE

 PS50202; MSP 

PRINTS