CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014759
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bridging integrator 2 
Protein Synonyms/Alias
  
Gene Name
 Bin2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
65HRLYKDLKNFLSAVKacetylation[1]
136VSQFSEVKERIAKRGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation (By similarity). Plays a role in podosome formation. Inhibits phagocytosis. 
Sequence Annotation
 DOMAIN 28 244 BAR.
 MOD_RES 273 273 Phosphoserine (By similarity).
 MOD_RES 375 375 Phosphoserine (By similarity).  
Keyword
 Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MAEGKAGGAA GLFAKQMQKK FSRAQEKVLQ KLGKTVETKD ERFEQSASNF YQQQAEGHRL 60
YKDLKNFLSA VKVMRESSKR VSETLQEIYN SDWDGHEDLK AIVGNNDLLW EDYEEKLADQ 120
ALRTMENYVS QFSEVKERIA KRGRKLVDYD SARHHLEAVQ NAKKKDEAKM AKAEEDFSKA 180
QVVFEDLNQE LLEELPVLYN SRIGCYVTVF QNISNLRDVF YREMSKLNHS LYEVMSKLEK 240
QHSNKVFVVK GLSSSSRRSL VISPPVQTCT AFSPVSPVTS PTSPNALSVT SESESVSATA 300
EELTSEAVGE DSCESEESLK DEEADEDQSE TSSSEEEEDE DEDEDEEESL AACNGPTPTP 360
APTPAPASPA AEVKSQEEAA PCSPTSSLGR GQTGKEHSPP GEVVLRARAS SEGAEQSKRT 420
ASVQRTSAPP SRPPPPKASG GGLSSPPGSA EASKACHPRA SSDASSDPEP PETGEKEGTG 480
SSGPKEPHAS STKSATQVVS NDENTEL 507 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0002102; C:podosome; ISS:UniProtKB.
 GO:0005543; F:phospholipid binding; ISS:UniProtKB.
 GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
 GO:0097320; P:membrane tubulation; ISS:UniProtKB.
 GO:0006911; P:phagocytosis, engulfment; IEA:Compara.
 GO:0071800; P:podosome assembly; ISS:UniProtKB. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR003005; Amphiphysin.
 IPR004148; BAR_dom. 
Pfam
 PF03114; BAR 
SMART
 SM00721; BAR 
PROSITE
 PS51021; BAR 
PRINTS
 PR01251; AMPHIPHYSIN.