UniProt Accession

 RAN_MOUSE; P62827; P17080; P28746; P28747; Q3U954; Q811M2; Q86V08; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9 

Genbank Protein ID

 L32751; S83456; AF159256; AK010569; AK010672; AK012268; AK012844; AK075900; AK087974; AK151341; AK151937; AK153197; AK153411; AK160647; AK167040; AK168183; BC014829; BC083356; M79316 

Genbank Nucleotide ID

 AAA64247.1; AAB50841.1; AAD45343.1; BAB27034.1; BAB27105.1; BAC36040.1; BAC40068.1; BAE30319.1; BAE30813.1; BAE31797.1; BAE31971.1; BAE35939.1; BAE39208.1; BAE40143.1; AAH14829.3; AAH83356.1; AAK14838.1 

Protein Name

 GTP-binding nuclear protein Ran 

Protein Synonyms/Alias

 GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein 

Gene Name

 Ran 

Gene Synonyms/Alias

 Rasl2-8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
23	VGDGGTGKTTFVKRH	acetylation	[1, 2]
23	VGDGGTGKTTFVKRH	succinylation	[2]
23	VGDGGTGKTTFVKRH	ubiquitination	[3]
28	TGKTTFVKRHLTGEF	acetylation	[1]
37	HLTGEFEKKYVATLG	acetylation	[1]
60	HTNRGPIKFNVWDTA	acetylation	[1, 2]
60	HTNRGPIKFNVWDTA	ubiquitination	[3]
71	WDTAGQEKFGGLRDG	acetylation	[2]
71	WDTAGQEKFGGLRDG	ubiquitination	[3]
99	VTSRVTYKNVPNWHR	acetylation	[1, 2]
99	VTSRVTYKNVPNWHR	ubiquitination	[3]
123	PIVLCGNKVDIKDRK	acetylation	[1]
127	CGNKVDIKDRKVKAK	ubiquitination	[3]
134	KDRKVKAKSIVFHRK	acetylation	[2]
134	KDRKVKAKSIVFHRK	succinylation	[2]
134	KDRKVKAKSIVFHRK	ubiquitination	[3]
142	SIVFHRKKNLQYYDI	acetylation	[2, 4]
142	SIVFHRKKNLQYYDI	succinylation	[2]
142	SIVFHRKKNLQYYDI	ubiquitination	[3]
152	QYYDISAKSNYNFEK	acetylation	[4]
152	QYYDISAKSNYNFEK	ubiquitination	[3]
159	KSNYNFEKPFLWLAR	acetylation	[1, 2]
159	KSNYNFEKPFLWLAR	succinylation	[2]
159	KSNYNFEKPFLWLAR	ubiquitination	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). 

Sequence Annotation

 NP_BIND 17 24 GTP (By similarity).
 NP_BIND 65 69 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 60 60 N6-acetyllysine (By similarity).
 MOD_RES 71 71 N6-acetyllysine; alternate (By
 MOD_RES 99 99 N6-acetyllysine (By similarity).
 MOD_RES 159 159 N6-acetyllysine (By similarity).
 CROSSLNK 71 71 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Isopeptide bond; Mitosis; Nucleotide-binding; Nucleus; Protein transport; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IMP:MGI.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0034629; P:cellular protein complex localization; IMP:MGI.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara.
 GO:0006606; P:protein import into nucleus; IDA:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR002041; Ran_GTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase. 

Pfam

 PF00071; Ras 

SMART

 SM00176; RAN 

PROSITE

 PS51418; RAN 

PRINTS

 PR00627; GTPRANTC4.