CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Diacylglycerol kinase theta 
Protein Synonyms/Alias
  
Gene Name
 DGKQ 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
205LLPGGFSKTQSFRIVubiquitination[1]
244QATPESGKQTLKIFDubiquitination[1]
347PRAQEVLKIYPGWLKubiquitination[1]
720YVRVGLQKISHSRSLubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 876 AA 
Protein Sequence
XPAAAPGHSF RKVTLTKPTF CHLCSDFIWG LAGFLCDVCN FMSHEKCLKH VRIPCTSVAP 60
SLVRVPVAHC FGPRGLHKRK FCAVCRKVLE APALHCEVCE LHLHPDCVPF ACSDCRQCHQ 120
DGHQDHDTHH HHWREGNLPS GARCEVCRKT CGSSDVLAGV RCEWCGVQAH SLCSAALAPE 180
CGFGRLRSLV LPPACVRLLP GGFSKTQSFR IVEAAEPGEG GDGADGSAAV GPGRETQATP 240
ESGKQTLKIF DGDDAVRRSQ FRLVTVSRLA GAEEVLEAAL RAHHIPEDPG HLELCRLPPS 300
SQACDAWAGG KAGSAVISEE GRSPGSGEAT PEAWVIRALP RAQEVLKIYP GWLKVGVAYV 360
SVRVTPKSTA RSVVLEVLPL LGRQAESPES FQLVEVAMGC RHVQRTMLMD EQPLLDRLQD 420
IRQMSVRQVS QTRFYVAESR DVAPHVSLFV GGLPPGLSPE EYSSLLHEAG ATKGAVVLDV 480
ACFAEAERLY MLLKDMAVRG RLLTALVLPD LLHAKLPPDS CPLLVFVNPK SGGLKGRDLL 540
CSFRKLLNPH QVFDLTNGGP LPGLHLFSQV PCFRVLVCGG DGTVGWVLGA LEETRYRLAC 600
PEPSVAILPL GTGNDLGRVL RWGAGYSGED PFSVLLSVDE ADAVLMDRWT ILLDAHEAGS 660
AENDTADAEP PKIVQMSNYC GIGIDAELSL DFHQAREEEP GKFTSRLHNK GVYVRVGLQK 720
ISHSRSLHKQ IRLQVERQEV ELPSIEGLIF INIPSWGSGA DLWGSDSDTR FEKPRMDDGL 780
LEVVGVTGVV HMGQVQGGLR SGIRIAQGSY FRVTLLKATP VQVDGEPWVQ APGHMIISAA 840
GPKVHMLRKA KQKPRRAGTT RDARADAAPA PESDPR 876 
Gene Ontology
 GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR020454; DAG/PE-bd.
 IPR000756; Diacylglycerol_kin_accessory.
 IPR001206; Diacylglycerol_kinase_cat_dom.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000159; Ras-assoc. 
Pfam
 PF00130; C1_1
 PF00609; DAGK_acc
 PF00781; DAGK_cat
 PF00788; RA 
SMART
 SM00109; C1
 SM00045; DAGKa
 SM00046; DAGKc
 SM00314; RA 
PROSITE
 PS50146; DAGK
 PS50200; RA
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS
 PR00008; DAGPEDOMAIN.