CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034702
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha 3 variant A 
Protein Synonyms/Alias
 Protein Itga3 
Gene Name
 Itga3 
Gene Synonyms/Alias
 ITGA3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
146VCAHRYTKVLWSGLEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell adhesion; Complete proteome; Integrin; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1052 AA 
Protein Sequence
MGPGPRRVPR DPGWMLRALA LMVAASGRVA FAFNLDTKFL VVKEAVNPGS LFGYSVALHR 60
QTERQQRYLL LAGAPRDLAV DDDYTNRTGA VYLCPLTALK NDCERMDISE KSDPDHHIIE 120
DMWLGVTVAS QGPAGRVLVC AHRYTKVLWS GLEDQRRMVG KCYVRGNDLQ LDPGDDWQTY 180
HNEMCNSNTD YLQTGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK DWDLSEYSYR 240
GSEDQGNLYI GYTMQVGSAI LHPSEITLVT GAPRHQHMGA VFLLKQESGG DLQRRQVLKG 300
TQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AVYVFMNQAG TSFPDQPSLL 360
LHGPSRSAFG ISVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSGGLL KQPQQIIHGE 420
TLGLPGLATF GYSLSGKMDV DENLYPDLLV GSLSDHIVLL RARPVINILH RTLVARPAVL 480
DPSLCTVTSC VQVELCFAYN QSAGNPNYRR NITLAYTVEA DRDRRPPRLR FARSQSSVFH 540
GFFSMPETHC QTLELLLMDN VRDKLRPIVI TMNYSLPLRM PDRLKLGLRS LDAYPVLNQA 600
QAMENHTEVH FQKECGPDNK CDSNLQMRAA FVSEQLQPLS RLQYSRDTKK LFLSINVTNS 660
PSRQRAGEDA HEALLTLEVS SALLLSSVRP AGTCQANETN TVCELGNPFK RNQRMELLIA 720
FEVTGVTLHT RDLRAHLQLS TSSHQDNLQP MFLTLQVDYT LQASLSLMNH RLQSFFSGTV 780
MGEAAMKTVK DVGSPLKYEF QVSPVGDGLA ALGTLVLGLE WPYEVTNGKW LLYPTEITIH 840
SNGSWPCQPH GNLVNPLNLT LSDPGVKPLS PQRRRRQLDP GGDQGPPPVT LAAAKKAKSE 900
TVLTCSNGRA RCVWLECPLP DASNITNVTV KARVWNSTFI EDYKDFDRVR VDGWATLFLR 960
TSIPTINMEN KTTWFSVDID SELVEELPAE IELWLVLVAV GAGLLLLGLI IILLWKCGFF 1020
KRARTRALYE AKRQKAEMRS QPSETERLTD DY 1052 
Gene Ontology
 GO:0034667; C:alpha3-beta1 integrin complex; IDA:RGD.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
 GO:0005518; F:collagen binding; IDA:RGD.
 GO:0001968; F:fibronectin binding; IDA:RGD.
 GO:0043236; F:laminin binding; IDA:RGD.
 GO:0019904; F:protein domain specific binding; IMP:RGD.
 GO:0007155; P:cell adhesion; IMP:RGD.
 GO:0007507; P:heart development; IEP:RGD.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
 GO:0031345; P:negative regulation of cell projection organization; IMP:RGD.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:RGD.
 GO:0010634; P:positive regulation of epithelial cell migration; IMP:RGD.
 GO:0010628; P:positive regulation of gene expression; IDA:RGD.
 GO:0010976; P:positive regulation of neuron projection development; IMP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0034698; P:response to gonadotropin stimulus; IEP:RGD. 
Interpro
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 
Pfam
 PF08441; Integrin_alpha2 
SMART
 SM00191; Int_alpha 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 
PRINTS
 PR01185; INTEGRINA.