UniProt Accession

 APOA2_HUMAN; P02652; B2R524 

Genbank Protein ID

 X04898; X00955; X02905; X02619; M29882; AY100524; AK312034; BT006786; AL590714; BC005282 

Genbank Nucleotide ID

 CAA28583.1; CAA25467.1; CAA26665.1; CAA26474.1; AAA51701.1; AAM49807.1; BAG34971.1; AAP35432.1; CAH72151.1; AAH05282.1 

Protein Name

 Apolipoprotein A-II 

Protein Synonyms/Alias

 Apo-AII; ApoA-II; Apolipoprotein A2; Truncated apolipoprotein A-II; Apolipoprotein A-II(1-76) 

Gene Name

 APOA2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	KDLMEKVKSPELQAE	glycation	[1]
62	PELQAEAKSYFEKSK	glycation	[1]
67	EAKSYFEKSKEQLTP	glycation	[1]
69	KSYFEKSKEQLTPLI	glycation	[1]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. 

Sequence Annotation

 REGION 32 43 O-glycosylated at one site.
 MOD_RES 24 24 Pyrrolidone carboxylic acid.
 MOD_RES 49 49 Methionine sulfoxide.
 MOD_RES 68 68 Phosphoserine.
 DISULFID 29 29 Interchain (with C-136 in APOD); in
 DISULFID 29 29 Interchain; in homodimeric form.  

Keyword

 3D-structure; Cleavage on pair of basic residues; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; HDL; Host-virus interaction; Lipid transport; Oxidation; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 100 AA 

Protein Sequence

Gene Ontology

 GO:0042627; C:chylomicron; IDA:BHF-UCL.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005769; C:early endosome; TAS:Reactome.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0034366; C:spherical high-density lipoprotein particle; IDA:BHF-UCL.
 GO:0034361; C:very-low-density lipoprotein particle; IDA:BHF-UCL.
 GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
 GO:0017127; F:cholesterol transporter activity; IEA:Compara.
 GO:0008035; F:high-density lipoprotein particle binding; IEA:Compara.
 GO:0055102; F:lipase inhibitor activity; IDA:BHF-UCL.
 GO:0005319; F:lipid transporter activity; IDA:BHF-UCL.
 GO:0031210; F:phosphatidylcholine binding; IDA:BHF-UCL.
 GO:0060228; F:phosphatidylcholine-sterol O-acyltransferase activator activity; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0002526; P:acute inflammatory response; IEA:Compara.
 GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
 GO:0008203; P:cholesterol metabolic process; IEA:Compara.
 GO:0046340; P:diacylglycerol catabolic process; IDA:BHF-UCL.
 GO:0034380; P:high-density lipoprotein particle assembly; IDA:BHF-UCL.
 GO:0034384; P:high-density lipoprotein particle clearance; IDA:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; IDA:BHF-UCL.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0034374; P:low-density lipoprotein particle remodeling; IDA:BHF-UCL.
 GO:0060621; P:negative regulation of cholesterol import; IDA:BHF-UCL.
 GO:0060695; P:negative regulation of cholesterol transporter activity; IDA:BHF-UCL.
 GO:0002740; P:negative regulation of cytokine secretion involved in immune response; IDA:BHF-UCL.
 GO:0060192; P:negative regulation of lipase activity; IDA:BHF-UCL.
 GO:0050995; P:negative regulation of lipid catabolic process; IDA:BHF-UCL.
 GO:0010903; P:negative regulation of very-low-density lipoprotein particle remodeling; IDA:BHF-UCL.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0018206; P:peptidyl-methionine modification; IDA:UniProtKB.
 GO:0006656; P:phosphatidylcholine biosynthetic process; IDA:BHF-UCL.
 GO:0009395; P:phospholipid catabolic process; IDA:BHF-UCL.
 GO:0033700; P:phospholipid efflux; IDA:BHF-UCL.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0010873; P:positive regulation of cholesterol esterification; IDA:BHF-UCL.
 GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IDA:UniProtKB.
 GO:0050996; P:positive regulation of lipid catabolic process; IDA:BHF-UCL.
 GO:0006457; P:protein folding; IDA:BHF-UCL.
 GO:0018158; P:protein oxidation; IDA:UniProtKB.
 GO:0030300; P:regulation of intestinal cholesterol absorption; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IDA:BHF-UCL.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IDA:BHF-UCL.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0043691; P:reverse cholesterol transport; IDA:BHF-UCL.
 GO:0006641; P:triglyceride metabolic process; TAS:BHF-UCL.
 GO:0034370; P:triglyceride-rich lipoprotein particle remodeling; IDA:BHF-UCL.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR006801; ApoA-II. 

Pfam

 PF04711; ApoA-II 

SMART

  

PROSITE

  

PRINTS