CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010716
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger X-linked protein ZXDA 
Protein Synonyms/Alias
  
Gene Name
 ZXDA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
316WTFTTSYKLKRHLQSacetylation[1]
318FTTSYKLKRHLQSHDacetylation[1]
489CPVEGCGKSFTRAEHubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes. 
Sequence Annotation
 ZN_FING 267 291 C2H2-type 1.
 ZN_FING 300 324 C2H2-type 2.
 ZN_FING 330 354 C2H2-type 3.
 ZN_FING 360 382 C2H2-type 4.
 ZN_FING 389 413 C2H2-type 5.
 ZN_FING 420 444 C2H2-type 6.
 ZN_FING 450 474 C2H2-type 7.
 ZN_FING 480 504 C2H2-type 8.
 ZN_FING 510 534 C2H2-type 9.
 ZN_FING 543 568 C2H2-type 10.
 REGION 267 573 Required for interaction with ZXDC.
 REGION 572 699 Required for transcriptional activation.  
Keyword
 Activator; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 799 AA 
Protein Sequence
MEIPKLLPAR GTLQGGGGGG IPAGGGRVHR GPDSPAGQVP TRRLLLPRGP QDGGPGRRRE 60
EASTASRGPG PSLFAPRPHQ PSGGGDDFFL VLLDPVGGDV ETAGSGQAAG PVLREEAKAG 120
PGLQGDESGA NPAGCSAQGP HCLSAVPTPA PISAPGPAAA FAGTVTIHNQ DLLLRFENGV 180
LTLATPPPHA WEPGAAPAQQ PRCLIAPQAG FPQAAHPGDC PELRSDLLLA EPAEPAPAPA 240
PQEEAEGLAA ALGPRGLLGS GPGVVLYLCP EALCGQTFAK KHQLKMHLLT HSSSQGQRPF 300
KCPLGGCGWT FTTSYKLKRH LQSHDKLRPF GCPAEGCGKS FTTVYNLKAH MKGHEQENSF 360
KCEVCEESFP TQAKLGAHQR SHFEPERPYQ CAFSGCKKTF ITVSALFSHN RAHFREQELF 420
SCSFPGCSKQ YDKACRLKIH LRSHTGERPF LCDFDGCGWN FTSMSKLLRH KRKHDDDRRF 480
MCPVEGCGKS FTRAEHLKGH SITHLGTKPF VCPVAGCCAR FSARSSLYIH SKKHLQDVDT 540
WKSRCPISSC NKLFTSKHSM KTHMVKRHKV GQDLLAQLEA ANSLTPSSEL TSQRQNDLSD 600
AEIVSLFSDV PDSTSAALLD TALVNSGILT IDVASVSSTL AGHLPANNNN SVGQAVDPPS 660
LMATSDPPQS LDTSLFFGTA ATGFQQSSLN MDEVSSVSVG PLGSLDSLAM KNSSPEPQAL 720
TPSSKLTVDT DTLTPSSTLC ENSVSELLTP AKAEWSVHPN SDFFGQEGET QFGFPNAAGN 780
HGSQKERNLI TVTGSSFLV 799 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS