CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007821
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 AP-3 complex subunit beta 
Protein Synonyms/Alias
 Adapter-related protein complex 3 subunit beta; Beta-3-adaptin; Clathrin assembly protein complex 3 beta large chain; Clathrin assembly protein large beta chain 
Gene Name
 APL6 
Gene Synonyms/Alias
 YKS5; YGR261C; G9331 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
715FTSSSNAKLTGINDGubiquitination[1]
730DSNSISGKGNVNTFTubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole. Required for the transport via the ALP pathway, which directs the transport of the cargo proteins PHO8 and VAM3 to the vacuole. 
Sequence Annotation
 REPEAT 37 76 HEAT 1.
 REPEAT 112 151 HEAT 2.
 REPEAT 153 186 HEAT 3.
 REPEAT 187 224 HEAT 4.
 REPEAT 524 561 HEAT 5.
 MOD_RES 693 693 Phosphoserine.
 MOD_RES 698 698 Phosphoserine.
 MOD_RES 724 724 Phosphoserine.
 MOD_RES 726 726 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 809 AA 
Protein Sequence
MVDSIHRIAS ALDTAKVITR EAAAVATSKL GESSYTYYSQ NINPQQLVTL LNSRNSREVR 60
DAMKRIISIM ASDDDSIDVQ LYFADVVKNI TTNDTKVKRL IHLYLLRFAE NDPNLTLLSI 120
NSLQKSLSDS NSELRCFALS ALSDMKMSSL APIILHTVKK LVTDPSAMVR GEVALAIIKL 180
YRAGKNDYHE ELLDILKELM ADTDPKVISC AVLAYKECYA DHLELLHGHF RRYCRIIKQL 240
DSWSQSYLIE LLIKYCKQYL PKPTVVDKSS EGSPRSCPLP DKYNEIEYPS YEVVNDPDLD 300
LFLQSLNCLI YSSNPTVILS CCNALYQLAS PLQMKNTKFI EALVRTVTMT ENQGNKEMLL 360
QAIHFLSILD QTLFLPYTKK FYVFPKDPIV ASIWKIQILS TLINESNVKE IFKELKYYVA 420
SAHFPENVVI MAVKSLSRCG QLSTSWESHV MKWLIDHMES HNLSASVLDA YVNVIRMLVQ 480
KNPTKHLRII FKLADLLTVQ TSLADNARAG IVWLFGEIAS IEFKICPDVL RRLIQNFSNE 540
GPETRCQILV LSAKLLSYDI DNFKQAQVTG SEENNQNPPY YDFSGSRISQ MYNAVLYLAK 600
YDDEFDIRDR ARMISSLFDS GKYEIVSLLL QAPKPTARSD DFIVSARLET HTPEIKEFFR 660
MLPWNTEITE VGETGNDIRE GAELKDYNKY KKSFSSQSFI TNNSARSFTS SSNAKLTGIN 720
DGDSNSISGK GNVNTFTSQN GKKYRLQSLD EFFSDIPERK SKPRKIIKVV EESSDEDEDE 780
SEESSDDDEY SDSSLGTSSS GTSSSHLEL 809 
Gene Ontology
 GO:0030123; C:AP-3 adaptor complex; IMP:SGD.
 GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD. 
Interpro
 IPR026740; AP3_beta.
 IPR026739; AP_beta.
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR002553; Clathrin/coatomer_adapt-like_N. 
Pfam
 PF01602; Adaptin_N 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS