CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027583
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carboxylesterase 6 
Protein Synonyms/Alias
 MCG23407; Protein Ces2a 
Gene Name
 Ces2a 
Gene Synonyms/Alias
 Ces6; mCG_23407 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
296HCLRAKSKQEILAINacetylation[1, 2]
296HCLRAKSKQEILAINsuccinylation[1]
296HCLRAKSKQEILAINubiquitination[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 558 AA 
Protein Sequence
MPLARLPGWL CVVACGLLLL LQHVHGQDSA SPIRNTHRGQ VRGSFVHVKD TKSGVHAFLG 60
IPFAKPPVGL LRFAPPEDPE PWSGVRDGTS QPAMCLQPDI MNLEDAKEMN LILPPISMSE 120
DCLYLNIYTP THAQEGSNLP VMVWIHGGGL VVGSASMNDV SKLAATEEIV IVAIQYRLGV 180
LGFFSTGDQH ARGNWGYLDQ VAALRWVQKN IAYFGGNRDR VTIFGVSAGG TSVSSHILSP 240
MSKGLFHGAI MQSGVALLPD LISDTSEVVY KTVANLSGCE ATDSEALIHC LRAKSKQEIL 300
AINQVFKMIP AVVDGEFLPK HPQELLTSMD FHPVPSIIGV NTDECGWGVP MFMGLDHIIK 360
NITRETLPAV LKNTAARMML PPECSHLLVE EYMGDTEDPE TLQAQFREML GDFMFVIPAL 420
QVAHFQRSQA PVYFYEFQHL SSFIKHVRPS HVKADHGDDV AFVFGSYLWD MNLDLTEEEE 480
LLKRMMMKYW ANFARNGNPN SEGLPSWPVL DHDEQYLQLD TQPAVGRALK ARRLQFWTKT 540
LPQKIQELKG SQDKHAEL 558 
Gene Ontology
 GO:0004091; F:carboxylesterase activity; IDA:MGI.
 GO:0006486; P:protein glycosylation; IDA:MGI. 
Interpro
 IPR002018; CarbesteraseB.
 IPR019826; Carboxylesterase_B_AS.
 IPR019819; Carboxylesterase_B_CS. 
Pfam
 PF00135; COesterase 
SMART
  
PROSITE
 PS00122; CARBOXYLESTERASE_B_1
 PS00941; CARBOXYLESTERASE_B_2 
PRINTS